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硬皮病患者血清对淋巴细胞诱导的血管生成的调节作用。II. 肢端硬皮病患者血清增强作用的效应细胞。

Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis. II. Effector cells for the enhancing effect of acroscleroderma patients' sera.

作者信息

Polakowski I J, Majewski S, Skopińska-Rózewska E, Zukowska M, Włodarska B, Jabłońska S

机构信息

Department of Gerontology, Medical Center of Postgraduate Education, Warsaw, Poland.

出版信息

Arch Dermatol Res. 1988;280(7):395-8. doi: 10.1007/BF00429976.

DOI:10.1007/BF00429976
PMID:2462852
Abstract

In our previous study, using the modified lymphocyte-induced angiogenesis assay, we found that incubation of normal human peripheral blood mononuclear cells (PBMCs) with sera from patients with acroscleroderma, but not with diffuse scleroderma, markedly enhanced their angiogenic capability. The results of the present work suggest that this enhancement is mediated by lymphocytes bearing receptors for the Fc portion of IgG and belonging mainly to the CD4+ T-cell subset.

摘要

在我们先前的研究中，我们使用改良的淋巴细胞诱导血管生成试验发现，用肢端硬皮病患者的血清而非弥漫性硬皮病患者的血清孵育正常人外周血单个核细胞（PBMCs），可显著增强其血管生成能力。目前这项工作的结果表明，这种增强是由带有IgG Fc部分受体且主要属于CD4 + T细胞亚群的淋巴细胞介导的。

相似文献

1
Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis. II. Effector cells for the enhancing effect of acroscleroderma patients' sera.硬皮病患者血清对淋巴细胞诱导的血管生成的调节作用。II. 肢端硬皮病患者血清增强作用的效应细胞。
Arch Dermatol Res. 1988;280(7):395-8. doi: 10.1007/BF00429976.
2
Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis.硬皮病患者血清对淋巴细胞诱导的血管生成的调节作用。
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本文引用的文献

1
Characterization of two subsets of human T gamma cells.人类Tγ细胞两个亚群的特征描述。
J Immunol. 1982 May;128(5):1979-85.
2
Antibody-dependent cellular cytotoxicity of human vascular endothelium in systemic sclerosis.系统性硬化症中人类血管内皮的抗体依赖性细胞毒性
Clin Exp Immunol. 1984 Sep;57(3):548-56.
3
Production of migration inhibition factor (MIF) by purified human T cell subpopulations.纯化的人T细胞亚群产生迁移抑制因子（MIF）。
Clin Exp Immunol. 1981 May;44(2):324-31.
4
A rapid method for separating functionally intact human T lymphocytes with monoclonal antibodies.一种用单克隆抗体分离功能完整的人T淋巴细胞的快速方法。
Clin Immunol Immunopathol. 1981 Nov;21(2):257-66. doi: 10.1016/0090-1229(81)90214-2.
5
Abnormalities of T lymphocyte subsets in patients with progressive systemic sclerosis (PSS, scleroderma).进行性系统性硬化症（硬皮病）患者T淋巴细胞亚群异常
J Lab Clin Med. 1981 Feb;97(2):264-77.
6
Endothelial injury in scleroderma. A protease mechanism.
J Lab Clin Med. 1983 Apr;101(4):553-60.
7
Characterization of E-rosette-positive Fc-receptor-bearing cells by flow cytometry.通过流式细胞术对E-玫瑰花结阳性且携带Fc受体的细胞进行表征。
Clin Immunol Immunopathol. 1982 Jan;22(1):105-17. doi: 10.1016/0090-1229(82)90027-7.
8
Lowered angiogeneic capability of peripheral blood lymphocytes in progressive systemic sclerosis (scleroderma).进行性系统性硬化症（硬皮病）中外周血淋巴细胞血管生成能力降低。
J Invest Dermatol. 1984 Mar;82(3):239-43. doi: 10.1111/1523-1747.ep12260139.
9
Activation of Fc receptor-bearing lymphocytes by immune complexes. I. Stimulation of lymphokine production by nonadherent human peripheral blood lymphocytes.免疫复合物对携带Fc受体淋巴细胞的激活作用。I. 非黏附性人外周血淋巴细胞产生淋巴因子的刺激作用。
J Immunol. 1982 Mar;128(3):1063-9.
10
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.从人血中分离单核细胞和粒细胞。通过一次离心分离单核细胞，通过离心和1g沉降相结合的方法分离粒细胞。
Scand J Clin Lab Invest Suppl. 1968;97:77-89.