Birkmann K, Junge H K, Maischberger E, Wehrli Eser M, Schwarzwald C C
Equine Department, Vetsuisse Faculty, Clinic for Equine Internal Medicine, University of Zurich, Zurich, Switzerland.
J Vet Intern Med. 2014 May-Jun;28(3):925-33. doi: 10.1111/jvim.12341. Epub 2014 Mar 14.
GastroGard, an omeprazole powder paste formulation, is considered the standard treatment for gastric ulcers in horses and is highly effective. Gastrozol, an enteric-coated omeprazole formulation for horses, has recently become available, but efficacy data are controversial and sparse.
To investigate the efficacy of GastroGard and Gastrozol at labeled doses (4 and 1 mg of omeprazole per kg bwt, respectively, PO q24h) in healing of gastric ulcers.
40 horses; 9.5 ± 4.6 years; 491 ± 135 kg.
Prospective, randomized, blinded study. Horses with an ulcer score ≥1 (Equine Gastric Ulcer Council) were randomly divided into 2 groups and treated for 2 weeks each with GastroGard followed by Gastrozol (A) or vice versa (B). After 2 and 4 weeks, scoring was repeated and compared with baseline. Plasma omeprazole concentrations were measured on the first day of treatment after administration of GastroGard (n = 5) or Gastrozol (n = 5).
Compared with baseline (squamous score (A) 1.65 ± 0.11, (B) 1.98 ± 0.11), ulcer scores at 2 weeks ((A) 0.89 ± 0.11, (B) 1.01 ± 0.11) and 4 weeks ((A) 1.10 ± 0.12, (B) 0.80 ± 0.12) had significantly decreased in both groups (P < .001), independent of treatment (P = .7). Plasma omeprazole concentrations were significantly higher after GastroGard compared with Gastrozol administration (AUCGG = 2856 (1405-4576) ng/mL × h, AUCGZ = 604 (430-1609) ng/mL × h; P = .03). The bioavailability for Gastrozol was 1.26 (95% CI 0.56-2.81) times higher than for GastroGard.
Both Gastrozol and GastroGard, combined with appropriate environmental changes, promote healing of gastric ulcers in horses. However, despite enteric coating of Gastrozol, plasma omeprazole concentrations after single labeled doses were significantly higher with GastroGard.
胃溃治（GastroGard），一种奥美拉唑粉糊制剂，被认为是治疗马胃溃疡的标准疗法且疗效显著。胃溃宁（Gastrozol），一种用于马的肠溶包衣奥美拉唑制剂，最近已上市，但疗效数据存在争议且稀少。
研究胃溃治和胃溃宁按标示剂量（分别为每千克体重4毫克和1毫克奥美拉唑，口服，每24小时一次）对马胃溃疡愈合的疗效。
40匹马；9.5±4.6岁；491±135千克。
前瞻性、随机、双盲研究。溃疡评分≥1（马胃溃疡委员会标准）的马被随机分为两组，每组分别先用胃溃治治疗2周，再用胃溃宁治疗2周（A组），或反之（B组）。在2周和4周后重复评分并与基线进行比较。在给予胃溃治（n = 5）或胃溃宁（n = 5）后治疗的第一天测量血浆奥美拉唑浓度。
与基线相比（鳞状上皮评分（A组）1.65±0.11，（B组）1.98±0.11），两组在2周时（（A组）0.89±0.11，（B组）1.01±0.11）和4周时（（A组）1.10±0.12，（B组）0.80±0.12）的溃疡评分均显著降低（P <.001），与治疗方式无关（P =.7）。与给予胃溃宁后相比，给予胃溃治后血浆奥美拉唑浓度显著更高（胃溃治的曲线下面积（AUCGG）= 2856（1405 - 4576）纳克/毫升×小时，胃溃宁的曲线下面积（AUCGZ）= 604（430 - 1609）纳克/毫升×小时；P =.03）。胃溃宁的生物利用度比胃溃治高1.26（95%可信区间0.56 - 2.81）倍。
胃溃宁和胃溃治，结合适当的环境改变，均可促进马胃溃疡的愈合。然而，尽管胃溃宁有肠溶包衣，但单次标示剂量后胃溃治的血浆奥美拉唑浓度显著更高。
