Doucet Michèle Y, Vrins André A, Dionne Rachel, Alva Roberto, Ericsson Glenn
Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, Saint-Hyacinthe, Québec J2S 7C6.
Can Vet J. 2003 Jul;44(7):581-5.
The efficacy of a paste formulation of the H+, K+, -ATPase inhibitor omeprazole was evaluated in standardbred racehorses for the treatment and prevention of gastric ulcers. Twenty standardbred racehorses in training, aged 2 to 9 years, were enrolled from 2 training centres in this field trial. Endoscopic examinations confirmed the presence of gastric ulcers in all horses, prior to allocation and treatment and on day 0. Lesions were scored on a scale of 0 to 3 (intact epithelium to extensive ulceration). Replicates were formed, based on training level and location. Within replicates, 1 horse was assigned to group 1 and 3 horses were assigned to group 2, randomly. Horses in group 1 were sham-dosed controls. Horses in group 2 were given omeprazole paste orally at 4 mg/kg bodyweight (BW)/day from day 0 to day 27 and 2 mg/kg BW/day of omeprazole paste orally from day 28 to day 57. Follow-up endoscopies were conducted on post treatment days 28 and 58 or 59. Physical examinations, including BWs, were conducted on all horses prior to treatment and on days 13 or 14, 28, 42 or 43, and 58 or 59. Horses treated with omeprazole had significantly (P < 0.01) more improvement in gastric lesion scores than did controls at day 28 and at study termination on days 58 or 59. All of the omeprazole-treated horses were improved relative to baseline ulcer score at both examinations, and 73.3% were healed (lesion score of 0) at both examinations. None of the controls improved at any point during the study. When the dose was reduced to 2 mg/kg BW, 80% of the horses showed no recurrences or worsening in gastric ulcers. It was concluded that omeprazole paste at 4 mg/kg BW orally, once daily is highly effective in healing gastric ulcers in standardbred racehorses in training and that a dose of 2 mg/kg BW orally, once daily, effectively prevents the recurrence of gastric ulcers in most horses.
在标准赛马中评估了H⁺、K⁺-ATP酶抑制剂奥美拉唑糊剂对胃溃疡的治疗和预防效果。在该现场试验中，从2个训练中心招募了20匹年龄在2至9岁的训练中的标准赛马。在内镜检查确认所有马匹在分配和治疗前以及第0天均存在胃溃疡。病变按0至3分进行评分（完整上皮至广泛溃疡）。根据训练水平和地点形成重复组。在重复组内，随机将1匹马分配到第1组，3匹马分配到第2组。第1组的马为假给药对照。第2组的马从第0天至第27天每天口服4mg/kg体重（BW）的奥美拉唑糊剂，从第28天至第57天每天口服2mg/kg BW的奥美拉唑糊剂。在治疗后第28天和第58天或第59天进行随访内镜检查。在治疗前以及第13或14天、第28天、第42或43天以及第58或59天对所有马匹进行包括体重在内的体格检查。在第28天以及在第58或59天研究结束时，用奥美拉唑治疗的马匹的胃病变评分改善程度显著高于对照组（P<0.01）。在两次检查中，所有用奥美拉唑治疗的马匹相对于基线溃疡评分均有改善，并且73.3%的马匹在两次检查中均愈合（病变评分为0）。在研究期间，对照组在任何时间点均无改善。当剂量降至2mg/kg BW时，80%的马匹未出现胃溃疡复发或恶化。得出的结论是，每天口服一次4mg/kg BW的奥美拉唑糊剂对训练中的标准赛马胃溃疡愈合非常有效，并且每天口服一次2mg/kg BW的剂量可有效预防大多数马匹胃溃疡的复发。
