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线性短杆菌肽与磷脂的混合单分子层。表面压力和表面电势研究。

Mixed monolayers of linear gramicidins and phospholipid. Surface pressure and surface potential studies.

作者信息

Van Mau N, Trudelle Y, Daumas P, Heitz F

机构信息

Laboratoire de Physicochimie des Systèmes Polyphasés, CNRS, France.

出版信息

Biophys J. 1988 Sep;54(3):563-7. doi: 10.1016/S0006-3495(88)82990-4.

Abstract

The behavior of two gramicidins incorporated into lipid monolayers is analyzed on the basis of the force and surface potential area curves. It is shown that the position of the gramicidins (helical axis parallel or perpendicular to the interface) depends on the monolayer pressure and that these molecules are not miscible with dioleoylphosphatidylcholine. Surface potential measurements suggest the existence of a relationship between the single channel characteristics and the surface potential and indicate that the tryptophans are essential for lowering the lipid surface potential in agreement with the single channel behaviour of both gramicidin A and gramicidin M.

摘要

基于力和表面电势-面积曲线,分析了掺入脂质单层中的两种短杆菌肽的行为。结果表明,短杆菌肽的位置(螺旋轴平行或垂直于界面)取决于单层压力,并且这些分子与二油酰磷脂酰胆碱不相溶。表面电势测量表明,单通道特性与表面电势之间存在关系,并表明色氨酸对于降低脂质表面电势至关重要,这与短杆菌肽A和短杆菌肽M的单通道行为一致。

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本文引用的文献

7
The conformation of gramicidin A.短杆菌肽A的构象。
Biochemistry. 1974 Dec 17;13(26):5249-56. doi: 10.1021/bi00723a001.
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Synthesis and characterization of Tyr(Bzl)9,11,13,15 and Tyr9,11,13,15 gramicidin A.
Int J Pept Protein Res. 1987 Aug;30(2):163-9. doi: 10.1111/j.1399-3011.1987.tb03325.x.
10
Linear gramicidins at the air-water interface.气-水界面处的线性短杆菌肽
Biophys J. 1987 May;51(5):843-5. doi: 10.1016/S0006-3495(87)83412-4.

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