Hallundbæk Mikkelsen Kristian, Nielsen Morten Frost, Tvede Michael, Hansen Torben, Pedersen Oluf Borbye, Holst Jens Juul, Vilsbøll Tina, Knop Filip Krag
Diabetologisk Forskningsenhed, Medicinsk Afdeling F, Gentofte Hospital, Niels Andersens Vej 65, 2900 Hellerup.
Ugeskr Laeger. 2013 Nov 11;175(46):2785-8.
New gene sequencing-based techniques and the large worldwide sequencing capacity have introduced a new era within the field of gut microbiota. Animal and human studies have shown that obesity and type 2 diabetes are associated with changes in the composition of the gut microbiota and that prebiotics, antibiotics or faecal transplantation can alter glucose and lipid metabolism. This paper summarizes the latest research regarding the association between gut microbiota, diabetes and obesity and some of the mechanisms by which gut bacteria may influence host metabolism.
基于新基因测序的技术以及全球范围内强大的测序能力开启了肠道微生物群领域的新纪元。动物和人体研究表明,肥胖和2型糖尿病与肠道微生物群组成的变化有关,益生元、抗生素或粪便移植可改变葡萄糖和脂质代谢。本文总结了关于肠道微生物群、糖尿病和肥胖之间关联的最新研究,以及肠道细菌可能影响宿主代谢的一些机制。