Han Jun-Ling, Lin Hui-Ling
Jun-Ling Han, Hui-Ling Lin, Department of Endocrinology and Metabolism, the 187 Hospital of PLA, Haikou 571159, Hainan Province, China.
World J Gastroenterol. 2014 Dec 21;20(47):17737-45. doi: 10.3748/wjg.v20.i47.17737.
The incidence of type 2 diabetes (T2DM) is rapidly increasing worldwide. However, the pathogenesis of T2DM has not yet been well explained. Recent evidence suggests that the intestinal microbiota composition is associated with obesity and T2DM. In this review, we provide an overview about the mechanisms underlying the role of intestinal microbiota in the pathogenesis of T2DM. There is clear evidence that the intestinal microbiota influences the host through its effect on body weight, bile acid metabolism, proinflammatory activity and insulin resistance, and modulation of gut hormones. Modulating gut microbiota with the use of probiotics, prebiotics, antibiotics, and fecal microbiota transplantation may have benefits for improvement in glucose metabolism and insulin resistance in the host. Further studies are required to increase our understanding of the complex interplay between intestinal microbiota and the host with T2DM. Further studies may be able to boost the development of new effective therapeutic approaches for T2DM.
2型糖尿病（T2DM）在全球的发病率正在迅速上升。然而，T2DM的发病机制尚未得到很好的解释。最近的证据表明，肠道微生物群组成与肥胖和T2DM有关。在本综述中，我们概述了肠道微生物群在T2DM发病机制中作用的潜在机制。有明确证据表明，肠道微生物群通过对体重、胆汁酸代谢、促炎活性和胰岛素抵抗以及肠道激素调节的影响来影响宿主。使用益生菌、益生元、抗生素和粪便微生物群移植来调节肠道微生物群可能有益于改善宿主的葡萄糖代谢和胰岛素抵抗。需要进一步研究以加深我们对肠道微生物群与T2DM宿主之间复杂相互作用的理解。进一步的研究或许能够推动T2DM新的有效治疗方法的发展。
