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扩展自闭症的“极端男性大脑”理论,将其作为其他主要风险因素之间的共同联系:一个假设。

Expanding upon the 'extreme male brain' theory of autism as a common link between other major risk factors: a hypothesis.

机构信息

Faculty of Science, Department of Mathematics and Statistics, University of Ottawa, Canada.

OMNI Research Group, Department of Obstetrics & Gynecology, University of Ottawa, Ottawa, Canada; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Canada; Department of Epidemiology and Community Medicine, University of Ottawa, Canada.

出版信息

Med Hypotheses. 2014 May;82(5):615-8. doi: 10.1016/j.mehy.2014.02.020. Epub 2014 Feb 26.

Abstract

On average, males have a stronger preference for physical systems and machines over interpersonal interactions; they have lower average levels of cognitive empathy or social cognition than females; and they have higher rates of 'extreme' intelligence when it comes to abstract concepts such as those found in mathematics and sciences. All three traits are also commonly associated with individuals with an autism spectrum disorder or ASD; clearly, it is not coincidental that incidence rates of autism are reportedly four times higher in males than in females. The common link between the majority of risk factors assessed in this review (including technological advancements, advanced parental age, socioeconomic status, and genetic predispositions towards ASDs in families of scientists and engineers) can be traced to a specific hormone, testosterone. It was established that traits which are typically associated with males are also typically associated with ASDs as well as individuals with antisocial personality disorder, or APD. The key distinction between individuals who are considered to be 'autistic' as opposed to those who are considered 'sociopathic' lies in the difference between their empathy deficits: whereas those who are 'autistic' are said to lack cognitive empathy (the ability to identify and understand the thoughts and feelings of others and to respond to these with appropriate emotions), those who are 'sociopathic' are said to lack emotional empathy (which is responsible for inhibiting acts of physical aggression or violence). This would explain why autistic individuals can have elevated testosterone levels without becoming physically aggressive.

摘要

平均而言,男性对物理系统和机器比对人际互动有更强的偏好;他们的认知同理心或社会认知水平平均低于女性;当涉及到抽象概念时,如数学和科学中的概念,他们具有更高的“极端”智力。这三个特征也通常与自闭症谱系障碍或 ASD 患者有关;显然,自闭症的发病率男性比女性高四倍并非偶然。本综述评估的大多数风险因素(包括技术进步、父母高龄、社会经济地位以及科学家和工程师家庭中 ASD 的遗传倾向)之间的共同联系可以追溯到一种特定的激素,即睾酮。研究表明,与男性相关的特征也与 ASD 以及反社会人格障碍或 APD 患者相关。被认为是“自闭症”的人与被认为是“反社会”的人之间的关键区别在于他们同理心缺陷的区别:被认为是“自闭症”的人被认为缺乏认知同理心(识别和理解他人的思想和感受的能力,并以适当的情绪对这些感受做出反应),而被认为是“反社会”的人则缺乏情感同理心(负责抑制身体攻击或暴力行为)。这可以解释为什么自闭症患者的睾丸激素水平升高而不会变得具有攻击性。

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