Department of Child and Adolescent Psychiatry, Erasmus Medical Centre - Sophia Children Hospital, 3000 CB Rotterdam, The Netherlands.
Department of Developmental Psychology, Tilburg School of Social and Behavioral Sciences, Tilburg University, 5037 AB Tilburg, The Netherlands.
Best Pract Res Clin Endocrinol Metab. 2014 Mar;28(2):221-32. doi: 10.1016/j.beem.2013.04.008. Epub 2013 May 16.
Animal models and epidemiological studies suggest that mild maternal thyroid hormone deficiency in early gestation has adverse consequences on the cognitive abilities of the children. However, methodological problems, lack of a consistent definition for mild thyroid hormone deficiency, and short follow-up of the children reduce the confidence in the conclusion of existing studies. In this review, we summarize the main findings of a series of studies performed in Generation R, a population-based birth cohort in Rotterdam, the Netherlands. In this iodine sufficient region, we aimed to investigate the relation between mild maternal thyroid hormone deficiency in early gestation and children's verbal and nonverbal cognitive function and executive function. We discuss the main findings of these studies, present recommendations for clinicians and formulate suggestions for future research.
动物模型和流行病学研究表明，妊娠早期轻度母体甲状腺激素缺乏对儿童的认知能力有不良影响。然而，方法学问题、缺乏对轻度甲状腺激素缺乏的一致定义以及对儿童的随访时间短，降低了现有研究结论的可信度。在这篇综述中，我们总结了在荷兰鹿特丹进行的一项基于人群的出生队列研究——Generation R 中的一系列研究的主要发现。在这个碘充足的地区，我们旨在研究妊娠早期轻度母体甲状腺激素缺乏与儿童言语和非言语认知功能及执行功能之间的关系。我们讨论了这些研究的主要发现，为临床医生提供了建议，并为未来的研究提出了建议。
