Fervaha Gagan, Foussias George, Siddiqui Ishraq, Agid Ofer, Remington Gary
Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada.
Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.
Schizophr Res. 2014 Apr;154(1-3):89-92. doi: 10.1016/j.schres.2014.02.013. Epub 2014 Mar 11.
The Heinrichs-Carpenter Quality of Life Scale (QLS) is the most extensively used real-world community functioning scale in schizophrenia research. However, the extensive time required to administer it and the inclusion of items that overlap conceptually with negative symptoms limit its use across studies. The present study examined the validity and utility of two abbreviated QLS measures against the full QLS excluding negative symptom items.
The sample included 1427 patients with schizophrenia who completed the baseline visit in the CATIE study. The validity of two abbreviated QLS measures (7-item and 4-item) were examined with the full QLS, excluding the intrapsychic foundations subscale, using correlation analysis. The utility of the abbreviated measures was explored by examining associations between the functioning scales and clinical variables and longitudinal change.
Both abbreviated QLS measures were highly predictive of the full QLS (both r=0.91, p<0.001), with no difference in predictive value between the abridged measures. Functional status was significantly associated with symptoms and cognition. Importantly, the strength of these associations was similar between the abbreviated and full QLS. Finally, multiple regression models examining the explanatory power of amotivation/apathy in predicting functioning scores after other symptoms and neurocognition had been accounted for were essentially identical irrespective of the QLS instrument used as the dependent measure. Longitudinal change was also similar across the three scales.
The 7-item abbreviated QLS is recommended as a brief measure of community functioning for individuals with schizophrenia, especially when assessment of functional outcome is not the focus.
海因里希斯-卡彭特生活质量量表（QLS）是精神分裂症研究中使用最广泛的现实世界社区功能量表。然而，实施该量表所需时间较长，且包含与阴性症状概念重叠的项目，这限制了其在各项研究中的应用。本研究检验了两种简化版QLS量表相对于排除阴性症状项目的完整QLS量表的有效性和实用性。
样本包括1427名在CATIE研究中完成基线访视的精神分裂症患者。使用相关分析，以排除心理内在基础分量表的完整QLS量表检验两种简化版QLS量表（7项和4项）的有效性。通过检验功能量表与临床变量及纵向变化之间的关联，探索简化版量表的实用性。
两种简化版QLS量表对完整QLS量表均具有高度预测性（两者r = 0.91，p < 0.001），简化版量表之间的预测价值无差异。功能状态与症状和认知显著相关。重要的是，简化版和完整QLS量表之间这些关联的强度相似。最后，在考虑了其他症状和神经认知因素后，检验无动机/冷漠对功能得分预测能力的多元回归模型，无论使用何种QLS量表作为因变量，结果基本相同。三种量表的纵向变化也相似。
推荐使用7项简化版QLS量表作为精神分裂症患者社区功能的简短测量工具，尤其是在功能结局评估并非重点时。
