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Blood flow in the rabbit tenuissimus muscle. Influence of preparative procedures for intravital microscopic observation.兔薄肌中的血流。活体显微镜观察制备程序的影响。
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Calcitonin gene-related peptide is a potent vasodilator.降钙素基因相关肽是一种强效血管舒张剂。
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Substance P and calcitonin gene-related peptide: immunohistochemical localisation and microvascular effects in rabbit skeletal muscle.P物质与降钙素基因相关肽：兔骨骼肌中的免疫组织化学定位及微血管效应
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):87-93. doi: 10.1007/BF00177756.
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Vasodilatory effects and coexistence of calcitonin gene-related peptide (CGRP) and substance P in sensory nerves of cat dental pulp.
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Calcitonin gene-related peptide is a potent inhibitor of substance P degradation.
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降钙素基因相关肽在体内使骨骼肌小动脉对P物质脱敏。

Calcitonin gene-related peptide desensitizes skeletal muscle arterioles to substance P in vivo.

作者信息

Ohlén A, Wiklund N P, Persson M G, Hedqvist P

机构信息

Department of Physiology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Br J Pharmacol. 1988 Nov;95(3):673-4. doi: 10.1111/j.1476-5381.1988.tb11691.x.

DOI:10.1111/j.1476-5381.1988.tb11691.x
PMID:2463027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854242/
Abstract

Calcitonin gene-related peptide (CGRP) was tested for possible interactions with the effects of substance P on rabbit skeletal muscle arterioles in vivo. Both CGRP and substance P dose-dependently increased arteriolar diameter. However, pretreatment with CGRP made the arterioles insensitive to substance P, and also prevented the formation of aggregates of leukocytes and platelets normally seen after substance P. These results suggest that CGRP, in addition to its direct effects, may act as a modulator of the effects of substance P in neurogenic inflammation.

摘要

对降钙素基因相关肽（CGRP）进行了检测，以研究其在体内与P物质对兔骨骼肌小动脉的作用之间可能存在的相互作用。CGRP和P物质均可使小动脉直径呈剂量依赖性增加。然而，用CGRP预处理可使小动脉对P物质不敏感，并且还可阻止通常在P物质作用后出现的白细胞和血小板聚集的形成。这些结果表明，CGRP除了具有直接作用外，在神经源性炎症中可能还作为P物质作用的调节剂。