Hunter Shereen Shoukry, Gadallah Amr, Azawi Maan Khalaf, Doss Wahid
Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Andrology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Arab J Gastroenterol. 2014 Mar;15(1):16-20. doi: 10.1016/j.ajg.2014.01.012. Epub 2014 Feb 13.
Hepatitis C virus (HCV) infection is a major public health problem worldwide and in Egypt. Several studies have suggested that chronic HCV infection may be associated with erectile dysfunction (ED) in men. The aim of our study was to detect the prevalence of ED among male patients with chronic HCV infection.
The study included 150 male patients with chronic HCV infection (124 patients with chronic hepatitis and 26 patients with HCV-associated liver cirrhosis). The Child-Pugh score was used to assess the severity of cirrhosis. An Arabic validated version of the five-item International Index of Erectile Function (IIEF-5) was used to detect the presence and severity of ED.
The patients' age ranged from 20 to 80 years with mean age±standard deviation (SD; 50±17.19) years. The prevalence of ED among patients with chronic HCV infection was found to be 29.3%. The prevalence was significantly higher in cirrhotic as compared to chronic hepatitis patients (p<0.001) and the average ED score was significantly lower in patients with liver cirrhosis than in those with chronic hepatitis. There was a highly significant relation between the severity of ED and the severity of liver disease. There was a significant negative correlation between serum bilirubin and ED score and a significant positive correlation between serum albumin and ED score in patients with liver cirrhosis.
About 30% of patients with chronic HCV infection were found to have ED; so, given the high prevalence of HCV infection in Egypt, chronic HCV infection may be considered in the differential diagnosis of ED. There was a highly significant relation between the severity of ED and the severity of liver disease and the majority of patients with liver cirrhosis proved to be suffering from ED, which may be related to the associated hypoalbuminaemia.
丙型肝炎病毒（HCV）感染是全球及埃及的一个主要公共卫生问题。多项研究表明，慢性HCV感染可能与男性勃起功能障碍（ED）有关。我们研究的目的是检测慢性HCV感染男性患者中ED的患病率。
该研究纳入了150例慢性HCV感染男性患者（124例慢性肝炎患者和26例HCV相关肝硬化患者）。采用Child-Pugh评分评估肝硬化的严重程度。使用经过阿拉伯语验证的五项国际勃起功能指数（IIEF-5）来检测ED的存在及严重程度。
患者年龄在20至80岁之间，平均年龄±标准差（SD；50±17.19）岁。发现慢性HCV感染患者中ED的患病率为29.3%。与慢性肝炎患者相比，肝硬化患者中ED的患病率显著更高（p<0.001），且肝硬化患者的平均ED评分显著低于慢性肝炎患者。ED的严重程度与肝病的严重程度之间存在高度显著的关系。肝硬化患者中血清胆红素与ED评分之间存在显著负相关，血清白蛋白与ED评分之间存在显著正相关。
发现约30%的慢性HCV感染患者患有ED；因此，鉴于埃及HCV感染的高患病率，在ED的鉴别诊断中可考虑慢性HCV感染。ED的严重程度与肝病的严重程度之间存在高度显著的关系，且大多数肝硬化患者被证明患有ED，这可能与相关的低白蛋白血症有关。
