沉默突变也能发出声响。
Silent mutations make some noise.
机构信息
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Cell. 2014 Mar 13;156(6):1129-1131. doi: 10.1016/j.cell.2014.02.037.
Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.
同义突变不改变氨基酸，通常被认为在癌症中是非功能性的。Supek 等人现在提出了一个有说服力的分析，表明这种沉默突变可以通过改变转录剪接从而影响蛋白质功能而致癌。
Zotero 插件