Geriatric Psychiatry Center, Psychiatric University Hospital St. Hedwig, Große Hamburger Str. 5-11, 10115 Berlin, Germany; Institute of Occupational Therapy, School of Health Professions, Zurich University of Applied Sciences, Technikumstrasse 71, 8401 Winterthur, Switzerland; Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469 Potsdam, Germany.
Geriatric Psychiatry Center, Psychiatric University Hospital St. Hedwig, Große Hamburger Str. 5-11, 10115 Berlin, Germany.
Eur Psychiatry. 2015 Feb;30(2):251-7. doi: 10.1016/j.eurpsy.2014.02.004. Epub 2014 Mar 13.
Here we evaluate an interdisciplinary occupational and sport therapy intervention for dementia patients suffering from apathy.
A prospective, controlled, rater-blinded, clinical trial with two follow-ups was conducted as part of a larger cluster-randomized trial in 18 nursing homes in Berlin. n=117 dementia patients with apathy, defined as a score of 40 or more on the apathy evaluation scale (AES) or presence of apathy on the Neuropsychiatric Inventory (NPI), were randomly assigned to intervention or control group. The intervention included 10 months of brief activities, provided once a week. The primary outcome measure was the total score on the AES scale measured directly after the intervention period and again after 12 months.
We found significant group differences with respect to apathy during the 10 month intervention period (F2,82=7.79, P<0.01), which reflected an increase in apathy in the control group, but not in the intervention group. Within one year after the intervention was ceased, the treatment group worsened and no longer differed significantly from the control group (P=0.55).
Our intervention was effective for the therapy of apathy in dementia, when applied, but not one year after cessation of therapy.
在此，我们评估了一种针对患有淡漠症的痴呆症患者的跨学科职业和运动疗法干预。
这是一项前瞻性、对照、评估者盲法、临床研究，作为柏林 18 家养老院中一项更大的集群随机试验的一部分进行了两次随访。n=117 名患有淡漠症的痴呆症患者，根据淡漠评估量表（AES）得分为 40 分或以上或神经精神疾病问卷（NPI）存在淡漠症，被随机分配到干预组或对照组。干预措施包括 10 个月的简短活动，每周提供一次。主要观察指标是干预结束后直接测量和 12 个月后 AES 量表的总分。
我们发现，在 10 个月的干预期间，两组在淡漠方面存在显著差异（F2,82=7.79，P<0.01），这反映了对照组的淡漠程度增加，而干预组没有。在干预停止后的一年内，治疗组恶化，与对照组不再有显著差异（P=0.55）。
我们的干预措施对于治疗痴呆症患者的淡漠症是有效的，但是在停止治疗一年后则不再有效。
