鲤鱼对葡聚糖的免疫反应。独特型异质性分析。
The immune response of carp against dextran. An analysis of the idiotype heterogeneity.
作者信息
Richter R F, Ambrosius H
机构信息
Section of Biosciences, Karl-Marx-Universität, Leipzig, GDR.
出版信息
Dev Comp Immunol. 1988 Fall;12(4):761-72. doi: 10.1016/0145-305x(88)90051-1.
The expression of a "species-specific" idiotype with specificity for alpha(1-6) dextran in carp is described. All tested carp anti-dextran antisera react with a rabbit anti-Id (carp anti-dex) serum. The rabbit anti-Id serum can be partially inhibited by the specific ligand, dextran T70 or isomaltodecaose but not or only weak with other, unrelated carbohydrates. These data confirm our statement, that a limited germline V-gene repertoire may code for antibodies in fish.
本文描述了鲤鱼中对α(1-6)葡聚糖具有特异性的“物种特异性”独特型的表达。所有测试的鲤鱼抗葡聚糖抗血清均与兔抗独特型（鲤鱼抗葡聚糖）血清发生反应。兔抗独特型血清可被特异性配体葡聚糖T70或异麦芽糖十糖部分抑制，但与其他无关碳水化合物则无抑制作用或仅有微弱抑制作用。这些数据证实了我们的观点，即有限的种系V基因库可能编码鱼类中的抗体。
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