[A further confirmation of the high idiotypic specificity of carp anti-human myeloma protein sera].

Previous investigations about the specificity of carp anti-idiotypic sera could be confirmed by comparison with corresponding antisera of guinea pigs. 3 carp antihuman myeloma-protein sera rendered as idiotypic specific after an appropriate absorption were tested in the passive hemagglutination inhibition test. They showed no difference to the parallel tested guinea pig antisera. It can be assumed that between fish antibodies and antibodies of mammals no functional difference exists in respect of antigen binding. On the other hand mammals exhibit a higher extent of structural antibody heterogeneity.