• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

腺病毒感染表现为孤立性中枢神经系统疾病，两名干细胞移植后的儿童无可检测的病毒血症。

Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation.

机构信息

Unité d'immunologie, Hématologie et Rhumatologie Pédiatriques, Hôpital Necker Enfants malades, 149 rue de Sèvres, 75015 Paris, France.

出版信息

J Clin Microbiol. 2011 Jun;49(6):2361-4. doi: 10.1128/JCM.00080-11. Epub 2011 Apr 13.

DOI:10.1128/JCM.00080-11
PMID:21490187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3122733/
Abstract

We report two cases of adenoviral meningoencephalitis in children following allogeneic stem cell transplantation. These cases showed four similarities: isolated neurological involvement, infiltrating hyperintensities next to the third ventricle on the cerebral magnetic resonance image, the absence of concomitant detectable adenoviral viremia, and a severe clinical outcome.

摘要

我们报告了两例异基因干细胞移植后儿童腺病毒脑膜脑炎。这些病例有四个共同点：孤立性神经受累、脑磁共振成像上第三脑室旁浸润性高信号、无同时可检测到的腺病毒血症以及严重的临床结局。

相似文献

1
Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation.腺病毒感染表现为孤立性中枢神经系统疾病，两名干细胞移植后的儿童无可检测的病毒血症。
J Clin Microbiol. 2011 Jun;49(6):2361-4. doi: 10.1128/JCM.00080-11. Epub 2011 Apr 13.
2
Meningoencephalitis due to adenovirus in a healthy infant mimicking severe bacterial sepsis.一名健康婴儿患腺病毒所致脑膜脑炎，临床表现酷似严重细菌性败血症。
Pediatr Infect Dis J. 2014 Apr;33(4):416-9. doi: 10.1097/INF.0000000000000128.
3
PCR diagnostics and monitoring of adenoviral infections in hematopoietic stem cell transplantation recipients.PCR 诊断和造血干细胞移植受者腺病毒感染的监测。
Arch Virol. 2010 Dec;155(12):2007-15. doi: 10.1007/s00705-010-0802-1. Epub 2010 Sep 17.
4
Adenovirus-associated meningoencephalitis in a healthy adult.
Ann Neurol. 1988 Jun;23(6):627-8. doi: 10.1002/ana.410230620.
5
Neonatal meningoencephalitis caused by human adenovirus species F infection.由人类腺病毒F种感染引起的新生儿脑膜脑炎。
Pediatr Int. 2019 Jan;61(1):99-101. doi: 10.1111/ped.13722. Epub 2019 Jan 10.
6
High titers of pre-existing adenovirus serotype-specific neutralizing antibodies in the host predict viral reactivation after allogeneic stem cell transplantation in children.在儿童异基因干细胞移植后，宿主中预先存在的腺病毒血清型特异性中和抗体的高滴度可预测病毒再激活。
Clin Infect Dis. 2011 Jun 15;52(12):1405-13. doi: 10.1093/cid/cir231.
7
Rotavirus meningoencephalitis in a previously healthy child and a review of the literature.
Pediatr Infect Dis J. 2009 Apr;28(4):318-21. doi: 10.1097/INF.0b013e31818ddbe9.
8
Design and application of a real-time polymerase chain for the detection and subsequent characterization of respiratory adenoviral infections.实时聚合酶链反应的设计和应用，用于检测和随后鉴定呼吸道腺病毒感染。
J Med Virol. 2014 Dec;86(12):2128-33. doi: 10.1002/jmv.23940. Epub 2014 Jun 11.
9
[Adenovirus infection in immunocompromised patients].免疫功能低下患者的腺病毒感染
Postepy Hig Med Dosw (Online). 2013 Sep 11;67:964-72. doi: 10.5604/17322693.1066199.
10
Use of polymerase chain reaction for diagnosis of disseminated adenovirus infection.
Pediatr Infect Dis J. 2002 Dec;21(12):1176-8. doi: 10.1097/00006454-200212000-00023.

引用本文的文献

1
Viral meningoencephalitis in pediatric solid organ or hematopoietic cell transplant recipients: a diagnostic and therapeutic approach.小儿实体器官或造血细胞移植受者的病毒性脑膜脑炎：诊断与治疗方法
Front Pediatr. 2024 Feb 12;12:1259088. doi: 10.3389/fped.2024.1259088. eCollection 2024.
2
Human Adenovirus Entry and Early Events during Infection of Primary Murine Neurons: Immunofluorescence Studies In Vitro.人腺病毒感染原代小鼠神经元过程中的进入及早期事件：体外免疫荧光研究
Pathogens. 2024 Feb 9;13(2):158. doi: 10.3390/pathogens13020158.
3
Ovarian tissue cryopreservation for fertility preservation before hematopoietic stem cell transplantation in patients with sickle cell disease: safety, ovarian function follow-up, and results of ovarian tissue transplantation.造血干细胞移植前对镰状细胞病患者进行卵巢组织冻存以保存生育力：安全性、卵巢功能随访和卵巢组织移植的结果。
J Assist Reprod Genet. 2024 Apr;41(4):1027-1034. doi: 10.1007/s10815-024-03054-4. Epub 2024 Feb 15.
4
Isolation and molecular characterization of Adenovirus in suspected acute flaccid paralysis patients: A preliminary report from Pakistan.疑似急性弛缓性麻痹患者腺病毒的分离与分子特征：来自巴基斯坦的初步报告。
Arch Virol. 2022 Feb;167(2):483-491. doi: 10.1007/s00705-021-05346-x. Epub 2022 Jan 4.
5
Multicenter prospective surveillance study of viral agents causing meningoencephalitis.多中心前瞻性监测研究致脑膜脑炎的病毒病原体。
Sci Rep. 2021 Mar 30;11(1):7216. doi: 10.1038/s41598-021-86687-0.
6
Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland.人类腺病毒的流行病学：瑞士伯尔尼住院患者的一项20年回顾性观察研究
Clin Epidemiol. 2020 Apr 5;12:353-366. doi: 10.2147/CLEP.S246352. eCollection 2020.
7
Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy.腺病毒视角：流行病学、致病性与基因治疗
Biomedicines. 2019 Aug 19;7(3):61. doi: 10.3390/biomedicines7030061.
8
Human adenovirus meningoencephalitis: a 3-years' overview.人腺病毒脑膜炎：3 年综述。
J Neurovirol. 2019 Aug;25(4):589-596. doi: 10.1007/s13365-019-00758-7. Epub 2019 May 17.
9
Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France.法国234例年龄小于30岁的镰状细胞贫血患者在清髓性预处理和同胞匹配移植后的长期无事件生存率、嵌合状态及生育结局
Haematologica. 2020 Jan;105(1):91-101. doi: 10.3324/haematol.2018.213207. Epub 2019 May 16.
10
Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention.腺病毒：流行病学、新型血清型的全球传播以及治疗与预防的进展
Semin Respir Crit Care Med. 2016 Aug;37(4):586-602. doi: 10.1055/s-0036-1584923. Epub 2016 Aug 3.

本文引用的文献

1
Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies.CMX001 对小鼠单纯疱疹病毒感染的疗效及其与药物分布研究的相关性。
J Infect Dis. 2010 Nov 15;202(10):1492-9. doi: 10.1086/656717. Epub 2010 Oct 5.
2
35-year-old HIV-positive woman with Basal forebrain mass.35 岁 HIV 阳性女性，基底前脑肿块。
Brain Pathol. 2010 Jan;20(1):265-8. doi: 10.1111/j.1750-3639.2009.00347.x.
3
Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation.实时 PCR 监测粪便中的腺病毒载量可使异基因干细胞移植后患者在即将发生侵袭性感染时及早发现。
Leukemia. 2010 Apr;24(4):706-14. doi: 10.1038/leu.2010.4. Epub 2010 Feb 11.
4
Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients.移植前鼻咽抽吸物中腺病毒 DNA 阳性：儿科患者腺病毒血症的一个非常强的危险因素。
Clin Infect Dis. 2009 Nov 15;49(10):1536-9. doi: 10.1086/644739.
5
Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients.非亲缘供者造血干细胞移植受者中腺病毒DNA的定量分析
J Clin Virol. 2008 Sep;43(1):79-85. doi: 10.1016/j.jcv.2008.04.014. Epub 2008 Jun 11.
6
Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome.异基因造血干细胞移植后播散性腺病毒感染：发病率、危险因素及预后
Haematologica. 2007 Sep;92(9):1254-7. doi: 10.3324/haematol.11279.
7
[A case of non-herpetic acute limbic encephalitis associated with a type-2 adenovirus infection].[一例与2型腺病毒感染相关的非疱疹性急性边缘叶脑炎病例]
Rinsho Shinkeigaku. 2006 May;46(5):322-7.
8
Acute meningoencephalitis caused by adenovirus serotype 26.
J Neurovirol. 2006 Jun;12(3):235-40. doi: 10.1080/13550280600846633.
9
Adenovirus infections in transplant recipients.移植受者中的腺病毒感染
Clin Infect Dis. 2006 Aug 1;43(3):331-9. doi: 10.1086/505498. Epub 2006 Jun 19.
10
Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity.异基因造血干细胞移植后儿童腺病毒感染：诊断、治疗与免疫
Bone Marrow Transplant. 2005 Mar;35 Suppl 1:S73-6. doi: 10.1038/sj.bmt.1704852.