中性粒细胞在肝脏疾病发展中的作用。
The role of neutrophils in the development of liver diseases.
机构信息
The Institute of Translational Hepatology, Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China.
The Institute of Intensive Care Unit, Beijing 302 Hospital, Beijing, China.
出版信息
Cell Mol Immunol. 2014 May;11(3):224-31. doi: 10.1038/cmi.2014.2. Epub 2014 Mar 17.
Abstract
Liver disease encompasses a wide variety of liver conditions, including liver failure, liver cirrhosis and a spectrum of acute and chronic hepatitis, such as alcoholic, fatty, drug, viral and chronic hepatitis. Liver injury is a primary causative factor in liver disease; generally, these factors include direct liver damage and immune-mediated liver injury. Neutrophils (also known as neutrophilic granulocytes or polymorphonuclear leukocytes (PMNs)) are the most abundant circulating white blood cell type in humans, and PMNs are a major innate immune cell subset. Inappropriate activation and homing of neutrophils to the microvasculature contributes to the pathological manifestations of many types of liver disease. This review summarizes novel concepts of neutrophil-mediated liver injury that are based on current clinical and animal model studies.
摘要
肝脏疾病包括多种肝脏疾病，包括肝功能衰竭、肝硬化和一系列急性和慢性肝炎，如酒精性、脂肪性、药物性、病毒性和慢性肝炎。肝损伤是肝脏疾病的主要致病因素；一般来说，这些因素包括直接肝损伤和免疫介导的肝损伤。中性粒细胞（也称为中性粒细胞或多形核白细胞（PMN））是人类循环中最丰富的白细胞类型，PMN 是主要的固有免疫细胞亚群。中性粒细胞在微血管中的异常激活和归巢导致许多类型的肝脏疾病的病理表现。这篇综述总结了基于当前临床和动物模型研究的中性粒细胞介导的肝损伤的新概念。
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