Na Jung Hwa, Sung Kyung Rim, Baek Seung Hee, Kim Soon Tae, Shon Kilwhan, Jung Jong Jin
Departments of *Ophthalmology ‡Clinical Epidemiology and Biostatistics, Asan Medical Center, College of Medicine, University of Ulsan †Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University, Seoul, Korea.
J Glaucoma. 2015 Apr-May;24(4):278-85. doi: 10.1097/IJG.0000000000000046.
To evaluate and compare the rates and patterns of macular and circumpapillary retinal nerve fiber layer (cRNFL) thickness thinning, assessed by spectral-domain optical coherence tomography (Cirrus SD-OCT), in eyes with preperimetric (PPG) and perimetric glaucoma (PG).
The present retrospective cohort study included 127 eyes of 75 patients (PPG, 87; PG, 40) with a mean follow-up of 2.53 years. All patients underwent at least 4 SD-OCT examinations. Linear mixed effects models were used to evaluate the rates of changes in relevant cRNFL and macular parameters.
Overall, after adjusting for covariates including age, baseline OCT data, and visual field severity, thickness changes in the 6 o'clock (-2.325 μm/y, cRNFL) and inferior outer sector (-2.879 μm/y, macular) showed the highest progression rates among all evaluated parameters. When -0.26 and -0.42 μm/y in average cRNFL and macular thickness changes were used as reference values for age-related physiological loss, 64.4% and 80.5% of PPG eyes and 60% and 70% of PG eyes, respectively, showed higher progression rates than these values. PG eyes showed significantly higher progression rates in the fovea and the inferior inner sector of the macula than did PPG eyes, although no progression rate of any cRNFL parameter differed between the 2 groups.
PG and PPG eyes showed different rates and patterns in macular thickness progression when assessed by Cirrus SD-OCT.
通过频域光学相干断层扫描（Cirrus SD-OCT）评估并比较视野缺损前期（PPG）和视野缺损期青光眼（PG）患者黄斑和视乳头周围视网膜神经纤维层（cRNFL）厚度变薄的速率和模式。
本回顾性队列研究纳入了75例患者的127只眼（PPG组87只眼；PG组40只眼），平均随访时间为2.53年。所有患者均接受了至少4次SD-OCT检查。采用线性混合效应模型评估相关cRNFL和黄斑参数的变化速率。
总体而言，在对年龄、基线OCT数据和视野严重程度等协变量进行校正后，在所有评估参数中，6点方位（-2.325μm/年，cRNFL）和颞下象限（-2.879μm/年，黄斑）的厚度变化显示出最高的进展速率。当平均cRNFL和黄斑厚度变化分别以-0.26和-0.42μm/年作为年龄相关生理变薄的参考值时，PPG组分别有64.4%和80.5%的眼、PG组分别有60%和70%的眼显示出高于这些值的进展速率。PG组黄斑中心凹和颞下象限的进展速率显著高于PPG组，尽管两组之间任何cRNFL参数的进展速率没有差异。
通过Cirrus SD-OCT评估时，PG组和PPG组在黄斑厚度进展方面表现出不同的速率和模式。
