Pellegrini Marco, Vagge Aldo, Ferro Desideri Lorenzo Ferro, Bernabei Federico, Triolo Giacinto, Mastropasqua Rodolfo, Del Noce Chiara Del, Borrelli Enrico, Sacconi Riccardo, Iovino Claudio, Di Zazzo Antonio Di, Forlini Matteo, Giannaccare Giuseppe
Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy.
University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy.
J Clin Med. 2020 Jun 2;9(6):1706. doi: 10.3390/jcm9061706.
Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible 'window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.
视网膜微循环与脑小血管具有相似的特征。因此，视网膜可被视为检测神经退行性疾病中发生的微血管损伤的一个可及的“窗口”。光学相干断层扫描血管造影（OCT-A）是一种非侵入性成像方式，可提供视网膜、脉络膜和视神经血流的深度分辨图像。在本综述中，我们总结了目前关于OCT-A在青光眼以及阿尔茨海默病、帕金森病和多发性硬化症等中枢神经系统疾病中的应用的文献。还讨论了旨在评估OCT-A是否可作为神经退行性疾病早期诊断和监测的额外生物标志物的未来方向。
