人类黑色素瘤独特的抗原表位存在于常见的黑色素瘤糖蛋白gp95/p97上。
A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.
作者信息
Furukawa K S, Furukawa K, Real F X, Old L J, Lloyd K O
机构信息
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
出版信息
J Exp Med. 1989 Feb 1;169(2):585-90. doi: 10.1084/jem.169.2.585.
Abstract
Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.
摘要
对黑色素瘤患者FD血清中存在的抗体进行分析表明，这些抗体能检测到仅存在于自体黑色素瘤细胞系SK-MEL-131上的独特肿瘤表位。先前的结果表明，独特的FD表位存在于一种约90kD的常见糖蛋白上，该糖蛋白在黑色素瘤和其他一些细胞类型中广泛表达。我们现在通过连续放射免疫沉淀和部分氨基酸测序表明，这种常见分子是一种先前已识别的黑色素瘤抗原，最初由小鼠单克隆抗体鉴定，命名为gp95或p97（也称为黑素转铁蛋白）。因此，FD是已被鉴定并与已知细胞表面分子相关的I类（独特）黑色素瘤抗原中的首个抗原。
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