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抽动障碍可能与自身免疫性甲状腺炎伴类固醇反应性脑病(SREAT)相关。

Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT).

作者信息

Saygi Semra, Ozkale Yasemin, Erol Ilknur

机构信息

Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Adana, Turkey,

出版信息

Indian J Pediatr. 2014 Oct;81(10):1105-7. doi: 10.1007/s12098-014-1374-y. Epub 2014 Mar 16.

Abstract

Steroid responsive encephalopathy with autoimmune thyroiditis (SREAT), a rare disorder in individuals of all age groups, including children, is characterized by high titers of anti-thyroid peroxidase antibodies. The present report concerns a previously healthy 12-y-old boy who presented with motor tics. The patient underwent an extensive work-up to identify the underlying etiologies and risk factors predisposing him to tic disorder. Based on the clinical and laboratory results, a diagnosis of SREAT was made. Although some studies have reported associated behavioral and cognitive changes, myoclonus, seizures, pyramidal tract dysfunction, psychosis, and coma. The authors describe a case of tic disorder, probably due to SREAT, as well as its course of treatment.

摘要

伴有自身免疫性甲状腺炎的类固醇反应性脑病(SREAT)是一种在包括儿童在内的所有年龄组个体中均罕见的疾病,其特征为抗甲状腺过氧化物酶抗体滴度升高。本报告涉及一名先前健康的12岁男孩,他出现了运动性抽动。该患者接受了全面检查以确定导致他患抽动障碍的潜在病因和危险因素。根据临床和实验室检查结果,诊断为SREAT。尽管一些研究报告了相关的行为和认知改变、肌阵挛、癫痫发作、锥体束功能障碍、精神病和昏迷。作者描述了一例可能由SREAT引起的抽动障碍病例及其治疗过程。

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