神经性贪食症患者伏隔核和尾状核的容积改变：一项结构磁共振成像研究
Volumetric alterations in the nucleus accumbens and caudate nucleus in bulimia nervosa: a structural magnetic resonance imaging study.
作者信息
Coutinho Joana, Ramos Ana Filipa, Maia Liliana, Castro Liliana, Conceição Eva, Geliebter Allan, Machado Paulo P P, Gonçalves Óscar, Sampaio Adriana
机构信息
Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
出版信息
Int J Eat Disord. 2015 Mar;48(2):206-14. doi: 10.1002/eat.22273. Epub 2014 Mar 17.
OBJECTIVE
Bulimia nervosa (BN) is an eating disorder characterized by recurrent episodes of binge eating and inappropriate compensatory behaviors (such as purging, fasting, or excessive exercise) to prevent weight gain. BN has been associated with deficits in inhibitory control processes. The basal ganglia specifically, the nucleus accumbens (NAc) and the caudate nucleus (CN) are part of the frontostriatal circuits involved in inhibitory control. The main goal of this study was to investigate the presence of morphological alterations in the NAc and the CN in a sample of patients diagnosed with BN.
METHOD
Forty-one female participants, 21 diagnosed with BN and 20 healthy matched controls (HC), underwent a structural magnetic resonance imaging (MRI) acquisition and clinical assessment. The NAc and the CN were manually segmented using the software Slicer 3D.
RESULTS
The results reveal a significant volumetric decrease in the CN and a preserved NAc volume in BN compared to the control group.
DISCUSSION
These findings suggest a contributory role of the caudate nucleus part of the dorsal striatum in the psychopathology of BN.
目的
神经性贪食症（BN）是一种饮食失调症，其特征为反复出现暴饮暴食以及为防止体重增加而采取的不适当代偿行为（如催吐、禁食或过度运动）。BN与抑制控制过程的缺陷有关。基底神经节，特别是伏隔核（NAc）和尾状核（CN）是参与抑制控制的额纹状体回路的一部分。本研究的主要目的是调查诊断为BN的患者样本中NAc和CN是否存在形态学改变。
方法
41名女性参与者，21名被诊断为BN，20名健康匹配对照（HC），接受了结构磁共振成像（MRI）采集和临床评估。使用Slicer 3D软件手动分割NAc和CN。
结果
结果显示，与对照组相比，BN患者的CN体积显著减小，而NAc体积保持不变。
讨论
这些发现表明背侧纹状体的尾状核部分在BN的精神病理学中起作用。
Zotero 插件