Cuenca-Navalon Elena, Finocchiaro Thomas, Laumen Marco, Fritschi Andreas, Schmitz-Rode Thomas, Steinseifer Ulrich
Int J Artif Organs. 2014 Jan;37(1):71-80. doi: 10.5301/ijao.5000301. Epub 2014 Jan 20.
A hybrid mock circulatory loop (MCL) was developed for total artificial heart (TAH) performance evaluation. The hybrid MCL consists of hydraulic hardware components and a software computer model.
The hydraulic components are divided into the systemic and pulmonary circulation, each of which includes electrically controlled compliances, resistors, and a venous volume which can be adjusted for a wide range of physiological and pathological conditions. The software model simulates the baroreflex autoregulatory response by automatically adjusting the hydraulic parameters according to changes of condition in the MCL.
The experimental results demonstrated a good representation of the human cardiovascular system and the capability of real-time variation of physiological and pathological conditions. The functionality of the baroreflex autoregulatory mechanism was evaluated by simulation of a postural change.
The hybrid MCL that we developed allows variable and continuous in vitro evaluation of mechanical circulatory support devices in TAH configuration and particularly their control algorithms in response to various cardiovascular conditions. The system has been built in a modular configuration to allow testing of different types of devices and thus provides a valuable test platform prior to animal experiments.
开发一种用于全人工心脏（TAH）性能评估的混合模拟循环回路（MCL）。该混合MCL由液压硬件组件和软件计算机模型组成。
液压组件分为体循环和肺循环，每个循环都包括电控顺应性、电阻器以及一个可针对多种生理和病理状况进行调节的静脉容积。软件模型通过根据MCL中的状况变化自动调整液压参数来模拟压力反射自动调节反应。
实验结果表明该模型能很好地模拟人体心血管系统，并具备实时改变生理和病理状况的能力。通过模拟体位变化评估了压力反射自动调节机制的功能。
我们开发的混合MCL允许对TAH配置中的机械循环支持装置进行可变且连续的体外评估，特别是评估其针对各种心血管状况的控制算法。该系统采用模块化配置构建，可用于测试不同类型的装置，从而在动物实验之前提供了一个有价值的测试平台。
