Perveen Tahira, Haider Saida, Zuberi Nudrat Anwar, Saleem Sadia, Sadaf Sana, Batool Zehra
Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan.
Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi-75510, Pakistan.
Sci Pharm. 2013 Nov 5;82(1):161-70. doi: 10.3797/scipharm.1304-19. Print 2014 Jan-Mar.
The seeds of Nigella sativa L., commonly known as black seed or black cumin, and its extracts are used in folk medicine in the Middle East and in Asian countries for the promotion of good health and as a remedy for many ailments. These seeds have many acclaimed medicinal properties such as broncho-dilatory, immunopotentiating, analgesic, anti-inflammatory, and hypotensive. In the present study, the antidepressant activity following the repeated administration of Nigella sativa L. oil has been monitored using the forced swim test. Rats treated with Nigella sativa L. oil exhibited a significant increase in struggling time after oral administration of Nigella sativa L. oil (0.1 ml/kg/day) for four weeks. Nigella sativa L. oil increased brain 5-HT levels and decreased 5-HT turnover (5-HT/5-HIAA ratio). Levels of tryptophan increased significantly in the brain and plasma following the repeated administration of Nigella sativa L. oil. Nigella sativa L. oil showed a potential antidepressant-like effect.
黑种草（Nigella sativa L.）的种子，通常被称为黑籽或黑孜然，及其提取物在中东和亚洲国家的民间医学中用于促进健康，并作为多种疾病的治疗方法。这些种子具有许多广受赞誉的药用特性，如支气管扩张、免疫增强、止痛、抗炎和降血压。在本研究中，使用强迫游泳试验监测了反复给予黑种草油后的抗抑郁活性。用黑种草油处理的大鼠在口服黑种草油（0.1 ml/kg/天）四周后，挣扎时间显著增加。黑种草油增加了大脑5-羟色胺（5-HT）水平并降低了5-HT周转率（5-HT/5-羟吲哚乙酸（5-HIAA）比率）。反复给予黑种草油后，大脑和血浆中的色氨酸水平显著增加。黑种草油显示出潜在的抗抑郁样作用。
