Aulakh C S, Wozniak K M, Hill J L, Devane C L, Tolliver T J, Murphy D L
Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Md.
Neuroendocrinology. 1988 Oct;48(4):401-6. doi: 10.1159/000125041.
The effect of various doses of the 5-HT agonist m-chlorophenylpiperazine (MCPP) on neuroendocrine function (prolactin and corticosterone responses) were compared in three different rat strains: Wistar, Sprague-Dawley (SD), and Fawn-Hooded (FH) rats. Administration of various doses of MCPP produced increases in plasma concentrations of prolactin and corticosterone in all three rat strains. The prolactin responses of FH rats to MCPP were significantly smaller than that of either Wistar or SD rats, while corticosterone responses were equivalent across all three strains. On the other hand, baseline concentrations of corticosterone, but not of prolactin, were significantly higher in FH animals relative to both Wistar and SD animals. There was no significant difference in either baseline hypothalamic concentrations of serotonin, 5-hydroxyindoleacetic acid, norepinephrine, or dopamine or brain concentrations of MCPP among these three rat strains. These findings support some other data indicating that FH rats, a strain with a peripheral platelet serotonin storage pool disorder, also possess alterations in some neuroendocrine functions which are modulated by serotonin.
在三种不同品系的大鼠（Wistar大鼠、斯普拉格-道利大鼠（SD大鼠）和淡色带帽大鼠（FH大鼠））中，比较了不同剂量的5-羟色胺（5-HT）激动剂间氯苯哌嗪（MCPP）对神经内分泌功能（催乳素和皮质酮反应）的影响。给予不同剂量的MCPP后，所有三种品系大鼠的血浆催乳素和皮质酮浓度均升高。FH大鼠对MCPP的催乳素反应明显小于Wistar大鼠或SD大鼠，而皮质酮反应在所有三种品系中相当。另一方面，相对于Wistar大鼠和SD大鼠，FH动物的皮质酮基线浓度显著更高，但催乳素基线浓度无显著差异。这三种品系大鼠的下丘脑5-羟色胺、5-羟吲哚乙酸、去甲肾上腺素或多巴胺的基线浓度以及脑中MCPP的浓度均无显著差异。这些发现支持了其他一些数据，表明FH大鼠作为一种具有外周血小板5-羟色胺储存池疾病的品系，其某些受5-羟色胺调节的神经内分泌功能也存在改变。
