Aulakh C S, Hill J L, Murphy D L
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. 20892.
Neuroendocrinology. 1993 May;57(5):869-74. doi: 10.1159/000126447.
Intravenous administration of the serotonergic agent m-chlorophenylpiperazine (m-CPP) to rats produced increases in plasma prolactin and corticosterone and a decrease in plasma growth hormone concentrations. Short-term (2-4 days) and long-term (21-23 days) lithium treatment did not affect baseline levels of prolactin, corticosterone or growth hormone. Long-term lithium treatment accentuated m-CPP's effect on plasma prolactin and corticosterone but not on growth hormone levels. On the other hand, short-term lithium treatment attenuated m-CPP's effect on plasma corticosterone but not on plasma prolactin or growth hormone levels. These findings demonstrate a differential effect of the duration of lithium treatment on m-CPP-induced neuroendocrine changes. One possible explanation for this differential effect may be that different 5-HT receptor subtypes are involved in mediating different neuroendocrine functions and, furthermore, these different 5-HT receptor subtypes may be affected differentially following lithium treatment. Alternatively, lithium-induced changes in other neurotransmitter systems may be responsible for this differential effect.
给大鼠静脉注射血清素能药物间氯苯哌嗪（m-CPP）可使血浆催乳素和皮质酮水平升高，血浆生长激素浓度降低。短期（2 - 4天）和长期（21 - 23天）锂治疗不影响催乳素、皮质酮或生长激素的基线水平。长期锂治疗增强了m-CPP对血浆催乳素和皮质酮的作用，但对生长激素水平无影响。另一方面，短期锂治疗减弱了m-CPP对血浆皮质酮的作用，但对血浆催乳素或生长激素水平无影响。这些发现表明锂治疗持续时间对m-CPP诱导的神经内分泌变化有不同影响。这种不同影响的一种可能解释可能是不同的5-羟色胺（5-HT）受体亚型参与介导不同的神经内分泌功能，此外，这些不同的5-HT受体亚型在锂治疗后可能受到不同影响。或者，锂诱导的其他神经递质系统变化可能是这种不同影响的原因。
