Wallace John L, Blackler Rory W, Chan Melissa V, Da Silva Gabriela J, Elsheikh Wagdi, Flannigan Kyle L, Gamaniek Iulia, Manko Anna, Wang Lu, Motta Jean-Paul, Buret Andre G
1 Department of Physiology & Pharmacology, University of Calgary , Calgary, Canada .
Antioxid Redox Signal. 2015 Feb 10;22(5):398-410. doi: 10.1089/ars.2014.5901. Epub 2014 Apr 15.
There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploited in drug development.
H2S synthesis and degradation are regulated in circumstances of inflammation and injury so as to promote repair and re-establish homeostasis. Novel H2S-releasing drugs exhibit enhanced anti-inflammatory and pro-restorative effects, while having reduced adverse effects in many tissues.
H2S is a pleiotropic mediator, having effects on many elements in the inflammatory cascade and promoting the resolution of inflammation and injury. It also contributes significantly to mucosal defence in the gastrointestinal tract, and in host defence against infection. There is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models, and several are progressing through human trials.
A better understanding of the physiological and pathophysiological roles of H2S continues to be restrained by the lack of simple, reliable methods for measurement of H2S synthesis, and the paucity of highly selective inhibitors of enzymes that participate in endogenous H2S synthesis. On the other hand, H2S donors show promise as therapeutics for several important indications.
越来越多的证据表明硫化氢在预防组织损伤、减轻炎症和促进修复方面发挥着重要作用。也有越来越多的证据表明硫化氢可成功用于药物开发。
在炎症和损伤情况下，硫化氢的合成和降解受到调节，以促进修复并重新建立体内平衡。新型硫化氢释放药物具有增强的抗炎和促修复作用，同时在许多组织中的不良反应减少。
硫化氢是一种多效性介质，对炎症级联反应中的许多因素有影响，并促进炎症和损伤的消退。它对胃肠道的黏膜防御以及宿主抗感染防御也有重要作用。有强有力的证据表明，新型基于硫化氢的疗法在动物模型中是安全有效的，并且有几种正在进行人体试验。
由于缺乏简单、可靠的硫化氢合成测量方法以及参与内源性硫化氢合成的酶的高选择性抑制剂较少，对硫化氢生理和病理生理作用的更好理解仍然受到限制。另一方面，硫化氢供体有望成为治疗几种重要病症的药物。
