Saito Miku, Yamaguchi Taihiko, Mikami Saki, Watanabe Kazuhiko, Gotouda Akihito, Okada Kazuki, Hishikawa Ryuki, Shibuya Eiji, Lavigne Gilles
Department of Gnatho-occlusal Function, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
J Sleep Res. 2013 Nov 4. doi: 10.1111/jsr.12099.
There is some evidence suggesting that obstructive sleep apnea-hypopnea syndrome is concomitant with sleep bruxism. The aim of this study was to investigate the temporal association between sleep apnea-hypopnea events and sleep bruxism events. In an open observational study, data were gathered from 10 male subjects with confirmed obstructive sleep apnea-hypopnea syndrome and concomitant sleep bruxism. Polysomnography and audio-video recordings were performed for 1 night in a sleep laboratory. Breathing, brain, heart and masticatory muscle activity signals were analysed to quantify sleep and sleep stage duration, and number and temporal distribution of apnea-hypopnea events and sleep bruxism events. Apnea-hypopnea events were collected within a 5-min time window before and after sleep bruxism events, with the sleep bruxism events as the pivotal reference point. Two temporal patterns were analysed: (i) the interval between apnea-hypopnea events termination and sleep bruxism events onset, called T1; and (ii) the interval between sleep bruxism events termination and apnea-hypopnea events onset, called T2. Of the intervals between sleep bruxism events and the nearest apnea-hypopnea event, 80.5% were scored within 5 min. Most intervals were distributed within a period of <30 s, with peak at 0-10 s. The T1 interval had a mean length of 33.4 s and was significantly shorter than the T2 interval (64.0 s; P < 0.05). Significantly more sleep bruxism events were scored in association with the T1 than the T2 pattern (P < 0.05). Thus, in patients with concomitant obstructive sleep apnea-hypopnea syndrome and sleep bruxism, most sleep bruxism events occurred after sleep apnea-hypopnea events, suggesting that sleep bruxism events occurring close to sleep apnea-hypopnea events is a secondary form of sleep bruxism.
有证据表明阻塞性睡眠呼吸暂停低通气综合征与睡眠磨牙症相伴。本研究旨在调查睡眠呼吸暂停低通气事件与睡眠磨牙症事件之间的时间关联。在一项开放性观察研究中，收集了10名确诊为阻塞性睡眠呼吸暂停低通气综合征并伴有睡眠磨牙症的男性受试者的数据。在睡眠实验室进行了1晚的多导睡眠图和视听记录。分析呼吸、大脑、心脏和咀嚼肌活动信号，以量化睡眠和睡眠阶段持续时间，以及呼吸暂停低通气事件和睡眠磨牙症事件的数量和时间分布。以睡眠磨牙症事件为关键参考点，在睡眠磨牙症事件前后5分钟的时间窗口内收集呼吸暂停低通气事件。分析了两种时间模式：（i）呼吸暂停低通气事件终止与睡眠磨牙症事件开始之间的间隔，称为T1；（ii）睡眠磨牙症事件终止与呼吸暂停低通气事件开始之间的间隔，称为T2。在睡眠磨牙症事件与最近的呼吸暂停低通气事件之间的间隔中，80.5%在5分钟内被记录。大多数间隔分布在<30秒的时间段内，峰值出现在0-10秒。T1间隔的平均长度为33.4秒，明显短于T2间隔（64.0秒；P<0.05）。与T2模式相比，与T1相关的睡眠磨牙症事件得分明显更多（P<0.05）。因此，在伴有阻塞性睡眠呼吸暂停低通气综合征和睡眠磨牙症的患者中，大多数睡眠磨牙症事件发生在睡眠呼吸暂停低通气事件之后，这表明在睡眠呼吸暂停低通气事件附近发生的睡眠磨牙症事件是睡眠磨牙症的一种继发形式。
