Massahud Maria Letícia de Barros, Bruzinga Fábio Fernandes Borém, Diniz Silvana Alkmim de Miranda, Seraidarian Karolina Kristian de Aguilar, Lopes Regina de Magalhães, Barros Vinícius de Magalhães, Seraidarian Paulo Isaias
Dentistry Department, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
Polysomnography Service, Madre Teresa Hospital, Belo Horizonte, Brazil.
J Oral Rehabil. 2022 May;49(5):505-513. doi: 10.1111/joor.13312. Epub 2022 Feb 18.
Sleep bruxism (SB) is a condition regulated centrally, with a multifactorial etiology, which can occur secondary to systemic disorders and the use of certain medications.
The aim of this study was to identify associations between SB, obstructive sleep apnea, and hypopnea syndrome (OSAHS) and the use of antidepressants.
In this cross-sectional study, 240 individuals underwent full-night polysomnography for medical reasons. Anamnesis was performed to collect data about the use of antidepressants and general health conditions. Polysomnography was performed to analyse sleep data and assess respiratory-related events and apnea and hypopnea index (AHI). The polysomnographic assessment of SB was performed, from electrodes placed on masseter muscles and chin. SB was defined by the presence of more than two events of rhythmic masticatory muscles activity per hour of sleep. Statistical analyses were performed to compare the presence of SB and AHI, the severity of OSAHS, and the use of antidepressants.
There were statistically significant differences between bruxers and non-bruxers when comparing AHI (48.28 ± 25.84; p = .001) and severity of OSAHS (p = .015). Regarding the use of antidepressants, comparative analyses did not show correlations with bruxism (p = .072). However, logistic regression suggests that the use of these medications may represent increased odds for SB development (OR =2.387; p = .005).
The relationship between the use of antidepressants and SB remains inconclusive. SB is associated with OSAHS, mainly in its severe form. Therefore, identifying SB can raise the suspicion of the occurrence of other systemic disturbances.
睡眠磨牙症（SB）是一种由中枢调节的病症，病因多因素，可继发于全身性疾病和某些药物的使用。
本研究旨在确定睡眠磨牙症、阻塞性睡眠呼吸暂停和呼吸不足综合征（OSAHS）与抗抑郁药使用之间的关联。
在这项横断面研究中，240名个体因医疗原因接受了整夜多导睡眠图检查。进行问诊以收集有关抗抑郁药使用和一般健康状况的数据。进行多导睡眠图检查以分析睡眠数据并评估呼吸相关事件以及呼吸暂停和呼吸不足指数（AHI）。通过放置在咬肌和下巴上的电极对睡眠磨牙症进行多导睡眠图评估。睡眠磨牙症的定义是每小时睡眠中出现超过两次节律性咀嚼肌活动事件。进行统计分析以比较睡眠磨牙症和AHI的存在情况、OSAHS的严重程度以及抗抑郁药的使用情况。
在比较AHI（48.28±25.84；p = 0.001）和OSAHS的严重程度（p = 0.015）时，磨牙症患者和非磨牙症患者之间存在统计学上的显著差异。关于抗抑郁药的使用，比较分析未显示与磨牙症有相关性（p = 0.072）。然而，逻辑回归表明，使用这些药物可能意味着睡眠磨牙症发生的几率增加（OR = 2.387；p = 0.005）。
抗抑郁药的使用与睡眠磨牙症之间的关系尚无定论。睡眠磨牙症与OSAHS相关，主要是在其严重形式中。因此，识别睡眠磨牙症可引发对其他全身性紊乱发生的怀疑。
