Mostafa T, Rashed L A, Osman I, Marawan M
Department of Andrology and Sexology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Andrologia. 2015 Mar;47(2):209-13. doi: 10.1111/and.12248. Epub 2014 Feb 19.
This study aimed to assess seminal plasma oxytocin (OT) and oxidative stress (OS) levels in infertile men with varicocele (Vx). A total of 131 men were divided into fertile men (n = 20), fertile men with Vx (n = 17), infertile men without Vx (n = 40) and infertile men with Vx (n = 54). OT, malondialdehyde (MDA) and glutathione peroxidase (GPx) were estimated in seminal plasma. Mean levels of seminal OT, MDA were significantly decreased, and the mean level of GPx was significantly increased in fertile men with/without Vx compared with infertile men with/without Vx. Mean levels of OT, MDA were increased, and mean level of GPx was significantly decreased in Vx grade III cases compared with Vx grades I, II cases and in bilateral Vx cases compared with unilateral Vx. There was significant negative correlation between seminal OT with sperm count, sperm motility, seminal GPx and significant positive correlation with sperm abnormal forms, seminal MDA. It is concluded that seminal OT is significantly decreased in fertile men with/without Vx compared with infertile men with/without Vx. Seminal OT demonstrated significant negative correlation with sperm count, sperm motility, seminal GPx and significant positive correlation with sperm abnormal forms, seminal MDA. Seminal OT is associated with Vx grade and its bilaterality.
本研究旨在评估精索静脉曲张（Vx）不育男性的精浆中催产素（OT）和氧化应激（OS）水平。总共131名男性被分为生育男性（n = 20）、患有Vx的生育男性（n = 17）、不患有Vx的不育男性（n = 40）以及患有Vx的不育男性（n = 54）。对精浆中的OT、丙二醛（MDA）和谷胱甘肽过氧化物酶（GPx）进行了测定。与患有/不患有Vx的不育男性相比，患有/不患有Vx的生育男性精浆中OT、MDA的平均水平显著降低，而GPx的平均水平显著升高。与I级、II级Vx病例相比，III级Vx病例以及与单侧Vx相比双侧Vx病例中，OT、MDA的平均水平升高，而GPx的平均水平显著降低。精浆OT与精子计数、精子活力、精浆GPx之间存在显著负相关，与精子畸形率、精浆MDA之间存在显著正相关。结论是，与患有/不患有Vx的不育男性相比，患有/不患有Vx的生育男性精浆中OT显著降低。精浆OT与精子计数、精子活力、精浆GPx之间表现出显著负相关，与精子畸形率、精浆MDA之间表现出显著正相关。精浆OT与Vx分级及其双侧性相关。
