精索静脉曲张不育患者精液可溶性 Fas 与氧化应激的关系。
Seminal soluble fas relationship with oxidative stress in infertile men with varicocele.
机构信息
Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
出版信息
Urology. 2013 Oct;82(4):820-3. doi: 10.1016/j.urology.2013.06.018. Epub 2013 Aug 1.
OBJECTIVE
To assess seminal plasma soluble Fas (sFas) relationship with oxidative stress and varicocele (Vx) grade in infertile men.
METHODS
In all, 230 men were prospectively investigated: fertile men without Vx, fertile men with Vx, infertile men without Vx, and infertile men with Vx. In their semen, seminal oxidant (malondialdehyde [MDA]), antioxidants (ascorbic acid, glutathione peroxidase [GPx], catalase [CAT], and superoxide dismutase [SOD]), and seminal sFas were assessed.
RESULTS
Either fertile or infertile men with Vx demonstrated significantly higher seminal oxidants (MDA) and significantly lower seminal antioxidants (SOD, GPx, CAT, and ascorbic acid), sFas compared with fertile or infertile men without Vx. Infertile men with or without Vx had significantly higher seminal MDA and significantly lower seminal antioxidants, sFas compared with fertile men with or without Vx. Men with Vx grade III had significantly higher seminal MDA and significantly lower antioxidants, sFas compared with Vx grade II and I, respectively. Seminal sFas demonstrated significant positive correlation with sperm count, sperm motility, sperm normal forms, seminal ascorbic acid, SOD, GPx, and CAT and significant negative correlation with seminal MDA.
CONCLUSION
Down regulation of seminal sFas in Vx associated men is related to increased oxidative stress and is correlated with Vx grade.
目的
评估精液可溶性 Fas（sFas）与精索静脉曲张（Vx）程度相关的氧化应激在不育男性中的关系。
方法
共前瞻性调查了 230 名男性：无 Vx 的生育男性、有 Vx 的生育男性、无 Vx 的不育男性和有 Vx 的不育男性。评估了他们精液中的氧化应激物（丙二醛 [MDA]）、抗氧化剂（抗坏血酸、谷胱甘肽过氧化物酶 [GPx]、过氧化氢酶 [CAT] 和超氧化物歧化酶 [SOD]）和精液 sFas。
结果
有或无 Vx 的生育或不育男性的精液氧化应激物（MDA）明显升高，抗氧化剂（SOD、GPx、CAT 和抗坏血酸）明显降低，sFas 明显高于无 Vx 的生育或不育男性。有或无 Vx 的不育男性的精液 MDA 明显升高，抗氧化剂明显降低，sFas 明显高于有或无 Vx 的生育男性。Vx 分级 III 的男性的精液 MDA 明显升高，抗氧化剂明显降低，分别与 Vx 分级 II 和 I 相比。精液 sFas 与精子计数、精子活力、精子正常形态、精液抗坏血酸、SOD、GPx 和 CAT 呈显著正相关，与精液 MDA 呈显著负相关。
结论
与 Vx 相关的男性精液 sFas 的下调与氧化应激增加有关，并且与 Vx 分级相关。
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