Aygun Dursun, Kocabicak Ersoy, Yildiz Mustafa Onur, Temel Yasin
Department of Neurology, Ondokuz Mayis University , Samsun , Turkey.
Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey; Department of Neurosurgery, Maastricht Medical Center, Maastricht, Netherlands; Department of Translational Neuroscience, Maastricht Medical Center, Maastricht, Netherlands.
Front Neurol. 2016 Jun 27;7:97. doi: 10.3389/fneur.2016.00097. eCollection 2016.
Deep brain stimulation (DBS) has become a preferred option for the treatment of motor symptoms in patients with advanced Parkinson's disease (PD). A good levodopa response (LR) is considered the most important criterion in determining the suitability of a patient for DBS. However, the effect of age and disease duration (DD) on the LR is still a subject of discussion.
Here, we investigated the effect of age and DD on the preoperative LR in PD patients to be selected for DBS.
From August 2011 to May 2015, 54 consecutive patients (29 men and 25 women) with advanced PD were evaluated for DBS of the STN and included in this retrospective study.
Thirty-seven patients were found suitable for DBS of the STN and 29 of them underwent bilateral surgery. We found no significant correlation between DD and the LR. However, there was a significant negative correlation between the patients' age and the LR.
The results indicate that the patients' age, rather than DD, has a negative effect on the LR. The study, therefore, indicates that PD patients with an advanced age and with a poor LR are not good candidates for DBS of the STN.
脑深部电刺激术（DBS）已成为晚期帕金森病（PD）患者运动症状治疗的首选方案。良好的左旋多巴反应（LR）被认为是判定患者是否适合接受DBS治疗的最重要标准。然而，年龄和病程（DD）对LR的影响仍是一个讨论话题。
在此，我们研究了年龄和DD对拟接受DBS治疗的PD患者术前LR的影响。
2011年8月至2015年5月，对54例连续的晚期PD患者（29例男性和25例女性）进行了丘脑底核DBS评估，并纳入这项回顾性研究。
发现37例患者适合接受丘脑底核DBS治疗，其中29例接受了双侧手术。我们发现DD与LR之间无显著相关性。然而，患者年龄与LR之间存在显著负相关。
结果表明，对LR产生负面影响的是患者的年龄，而非DD。因此，该研究表明，年龄较大且LR较差的PD患者不是丘脑底核DBS治疗的合适人选。
