School of Nursing, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Psychiatry, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA.
Department of Psychology, Ohio University, Athens, OH 45701, USA.
Psychoneuroendocrinology. 2014 Apr;42:118-23. doi: 10.1016/j.psyneuen.2014.01.006. Epub 2014 Jan 22.
Accumulating evidence suggests an adverse association between depressive symptoms and cognition, but a positive association between insulin-like growth factor (IGF)-1 and cognition. The present study examined the influence of IGF-1 in the relationship between depressive symptoms and learning and memory.
A cross-sectional study of 94 healthy fit older adults. Blood was collected and plasma IGF-1 was measured. Depressive symptoms were assessed with the Geriatric Depression Scale (GDS), and learning and memory were assessed using the Rey Auditory Verbal Learning Test (AVLT).
Among older adults with lower IGF-1 levels, higher depressive symptoms scores were associated with lower AVLT delayed recall and recognition. Older adults with higher IF-1 levels showed no associations between depressive symptoms and memory.
The association between depressive symptoms and cognition is stronger among older adults with lower levels of circulating IGF-1. Further validation studies on groups with depression or different stages of cognitive impairment are needed. IGF-1 may be a novel intervention target for slowing cognitive decline in older adults with depressive symptoms.
越来越多的证据表明抑郁症状与认知之间存在不良关联，但胰岛素样生长因子 (IGF)-1 与认知之间存在正相关。本研究探讨了 IGF-1 在抑郁症状与学习和记忆之间关系中的影响。
对 94 名健康的老年人进行横断面研究。采集血液并测量血浆 IGF-1。使用老年抑郁量表 (GDS) 评估抑郁症状，使用 Rey 听觉言语学习测试 (AVLT) 评估学习和记忆。
在 IGF-1 水平较低的老年人中，较高的抑郁症状评分与 AVLT 延迟回忆和识别较低有关。IGF-1 水平较高的老年人中，抑郁症状与记忆之间没有关联。
在循环 IGF-1 水平较低的老年人中，抑郁症状与认知之间的关联更强。需要对患有抑郁症或认知障碍不同阶段的人群进行进一步的验证研究。IGF-1 可能是减缓有抑郁症状的老年人认知能力下降的新干预靶点。
