组蛋白变体 H3.3 及其与 H2A.Z 在增强子和启动子上的共调控的动力学。
Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters.
机构信息
National Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China.
National Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China; University of Chinese Academy of Sciences; Beijing, China.
出版信息
Nucleus. 2014 Jan-Feb;5(1):21-7. doi: 10.4161/nucl.28067. Epub 2014 Feb 3.
Abstract
In eukaryotes, genomic DNA is hierarchically packaged into chromatin by histones. A defined organization of the genome into chromatin with specific patterns of epigenetic modifications is crucial for transcriptional regulation, cell fate determination, and maintenance, in which the histone variant incorporation has been characterized as one of the most key players. The diversity of histone variants results in structural plasticity of chromatin and highlights functionally distinct chromosomal domains. Here we focus on the role of histone variant H3.3 and its coregulation with H2A.Z in chromatin dynamics at enhancers and promoters and transcriptional regulation.
摘要
在真核生物中，基因组 DNA 通过组蛋白被分层包装成染色质。基因组在染色质中以特定的表观遗传修饰模式进行特定的组织，对于转录调控、细胞命运决定和维持至关重要，其中组蛋白变体的掺入被认为是最重要的因素之一。组蛋白变体的多样性导致染色质的结构可塑性，并突出了功能上不同的染色体结构域。在这里，我们重点介绍组蛋白变体 H3.3 的作用及其与 H2A.Z 在增强子和启动子处染色质动力学和转录调控中的核心调控作用。
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