[Inhibition of pancreatic secretion by trypsin and trypsinogen].

In dogs, trypsinogen inhibited the secretion of proteases more selectively and for a longer period than trypsin, whereas trypsin reduced tryptic activity of the blood to a lesser extent than trypsinogen. In contrast to trypsinogen, trypsin increased renal excretion of amylase and lipase. The difference between the effects may be due to the action of the trypsinogen hexapeptide formed during its turning into trypsin. Dynamic self-regulation of pancreatic secretion seems to depend on the ratio of trypsin, trypsinogen, its hexapeptide and products of alimentary proteins hydrolysis in duodenal contents.