[Dependence of pancreatic amylase secretion on the amylolytic activity of the duodenal contents].

Pancreatic amylase secretion stimulated by intraduodenal administration of acidified (up to pH 2.0) hydrolysine was evaluated in acute experiments on dogs. Bicarbonates, protein, amylase, lipase, and proteinase were assayed in the juice. Renal excretion of amylase and amylolytic activity of blood plasma were determined during the experiment. Intraduodenal administration of pancreatic amylase decreased amylase secretion by the pancreas and did not influence the secretion of bicarbonates and other enzymes. Administration into the duodenum of amylase with its inhibitor eliminated the effect of selective inhibition of pancreatic amylase secretion. Amylolytic activity of the blood was unchanged, while the renal amylase excretion increased.