ART周期长效方案中半量曲普瑞林与短效醋酸亮丙瑞林妊娠结局的比较：一项随机临床试验
Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial.
作者信息
Eftekhar Maryam, Rahmani Elham, Mohammadian Farnaz
机构信息
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, Iran.
出版信息
Iran J Reprod Med. 2013 Feb;11(2):133-8.
BACKGROUND
Gonadotrophin-releasing hormone (GnRH) agonist is used for controlling ovarian stimulation in assisted reproductive technology (ART) cycles which has some benefits.
OBJECTIVE
To compare the efficacy of two different formulations of GnRH agonist: short-acting and long-acting, for ART protocols.
MATERIALS AND METHODS
In a prospective randomized study, one hundred women who underwent ART cycles were randomly divided into two groups. In group I, the patients received one single injection of 1.87 mg Triptorelin in previous mid-luteal phase. In group II, Decapeptyl 0.1 mg per day started from previous mid-luteal phase. Pregnancy outcome in in vitro fertilization (IVF) cycle was compared between two groups.
RESULTS
There were no statistically significant differences in the number of retrieved oocyte (p=0.545), fertilization (p=0.876), implantation (p=0.716) and pregnancy rate (p=0.727) between the two groups.
CONCLUSION
There were not any advantages in IVF outcome between half-dose long-acting and short-acting GnRH agonist groups in ART cycle.
背景
促性腺激素释放激素（GnRH）激动剂用于辅助生殖技术（ART）周期中的卵巢刺激控制，具有一定益处。
目的
比较两种不同剂型的GnRH激动剂（短效和长效）在ART方案中的疗效。
材料与方法
在一项前瞻性随机研究中，100例行ART周期的女性被随机分为两组。第一组患者在前一个黄体中期接受一次1.87 mg曲普瑞林注射。第二组从之前的黄体中期开始每天注射0.1 mg 醋酸亮丙瑞林。比较两组体外受精（IVF）周期的妊娠结局。
结果
两组之间在获卵数（p = 0.545）、受精率（p = 0.876）、着床率（p = 0.716）和妊娠率（p = 0.727）方面无统计学显著差异。
结论
在ART周期中，半量长效GnRH激动剂组和短效GnRH激动剂组在IVF结局方面没有任何优势。
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