Kimirilova O G, Romantsov M G, Kharchenko G A
Antibiot Khimioter. 2013;58(3-4):43-8.
Cytochemical indices of peripheral blood leukocytes were investigated. The results allowed to estimate the level of the disease severity and to control the immunotropic therapy efficacy. Dysbalance of the interleukocytic microbicidical systems (IMS) of neutrophils reflected the nonspecific resisistance and the state of the phagocytic system as an objective criterion of the adaptation syndrome. Association of the deficiency of the IMS components and blood serum fibronectin were considered as a predisposition of bacterial complications. Cycloferon activated the phagocyte metabolic activity and promoted elimination of the main clinical symptoms of the disease (acute infective damage of the meninges, temperature elevation, intoxication signs), thus making shorter the hospitalization terms.
对外周血白细胞的细胞化学指标进行了研究。结果有助于评估疾病严重程度，并控制免疫调节治疗的疗效。中性粒细胞的白细胞间微生物杀伤系统（IMS）失衡反映了非特异性抵抗力以及吞噬系统的状态，这是适应综合征的一个客观标准。IMS 成分缺乏与血清纤维连接蛋白的关联被认为是细菌并发症的一个易患因素。环孢素激活了吞噬细胞的代谢活性，并促进了疾病主要临床症状（脑膜急性感染性损伤、体温升高、中毒症状）的消除，从而缩短了住院时间。
