Kvetnaia A S, Bekhtereva M K, Zhelezova L I, Kalinogorskaia O S
Antibiot Khimioter. 2012;57(3-4):9-16.
The efficacy of cycloferon in complex therapy of salmonellosis and yersiniosis in children (n=220) was investigated under clinical and laboratory conditious. It was shown, that cycloferon had direct and indirect immunotropic action in salmonellosis and yersiniosis in children. In contrast to the conventional antibiotic therapy, the use of cycloferon provided a more rapid relief of the local and systemic symptoms, reduction of superinfection or exacerbation. It had a positive effect on the antiinfective resistance of the colon mucosa resulting in normalization of the colon lumen microecology. The use of cycloferon provided eradication of the pathogen and opportunistic organisms. In the treatment of salmonellosis it enhanced formation of rare bacterial reconvalescent Shigella.
在临床和实验室条件下，对220例儿童沙门氏菌病和耶尔森氏菌病采用环孢素进行综合治疗的疗效进行了研究。结果表明，环孢素在儿童沙门氏菌病和耶尔森氏菌病中具有直接和间接的免疫调节作用。与传统抗生素治疗相比，使用环孢素能更快缓解局部和全身症状，减少二重感染或病情加重。它对结肠黏膜的抗感染抵抗力有积极影响，使结肠腔微生态恢复正常。使用环孢素能根除病原体和机会性微生物。在治疗沙门氏菌病时，它促进了罕见细菌恢复期志贺氏菌的形成。
