Kinoshita Shigeru, Amano Shiro, Inoue Yoshitsugu, Ohashi Yuichi, Takahashi Hiroshi, Tsubota Kazuo, Nishida Kohji
Nippon Ganka Gakkai Zasshi. 2014 Feb;118(2):81-3.
While corneal endothelial damage in its most advanced stage results in bullous keratopathy where corneal transplantation is needed, there is no severity grading for corneal endothelial damage. The Japanese Corneal Society formed a working group to establish a severity grading for corneal endothelial damage. The following are the proposed severity grading criteria. Normal: Corneal endothelial cell (CEC) density is 2000 cells/mm2 or more. Grade 1: CEC density between 1000 and 2000 cells/ mm2. The corneal endothelium is below the normal physiological condition. Grade 2: CEC density between 500 and 1000 cells/ mm2. The transparency of the corneal endothelium is endangered. Even slight damage can induce bullous keratopathy. Grade 3: CEC density below 500 cells/mm2 but no corneal edema is observed. Grade 4: Bullous keratopathy. The cornea is opaque with edema.
虽然角膜内皮损伤最严重阶段会导致大疱性角膜病变，需要进行角膜移植，但目前尚无角膜内皮损伤的严重程度分级。日本角膜学会成立了一个工作组来制定角膜内皮损伤的严重程度分级。以下是提议的严重程度分级标准。正常：角膜内皮细胞（CEC）密度为2000个细胞/mm²或更高。1级：CEC密度在1000至2000个细胞/mm²之间。角膜内皮低于正常生理状态。2级：CEC密度在500至1000个细胞/mm²之间。角膜内皮的透明度受到威胁。即使轻微损伤也可诱发大疱性角膜病变。3级：CEC密度低于500个细胞/mm²，但未观察到角膜水肿。4级：大疱性角膜病变。角膜因水肿而混浊。
