从胡桐 Millettia dielsiana Harms 的茎中导向分离抗发炎黄酮类化合物的生物活性。
Bioactivity-guided isolation of anti-inflammation flavonoids from the stems of Millettia dielsiana Harms.
机构信息
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China; Guangdong Zhongsheng Pharmaceutical Co Ltd, Dongguan 440100, Guangdong, China.
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
出版信息
Fitoterapia. 2014 Jun;95:154-9. doi: 10.1016/j.fitote.2014.03.008. Epub 2014 Mar 16.
Bioactivity-guided isolation of the EtOAc extract of the stems of Millettia dielsiana Harms yielded two new isoflavones together with nine known ones. Their structures were elucidated by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide and TNF-α in murine macrophage RAW 264.7 cells. Among the tested compounds, Millesianin C (1) had the most potent anti-inflammatory effect decreasing NO production similar to that of dexamethasone and decreasing TNF-α secretion better than that of dexamethasone. Their structure-activity relationship was also analyzed.
从密花豆（Millettia dielsiana Harms）茎的 EtOAc 提取物中经生物活性导向分离得到两种新的异黄酮，以及 9 种已知的异黄酮。通过分析包括 2D NMR 在内的光谱数据阐明了它们的结构。所有分离出的化合物均进行了评估，以检测其抑制 LPS 诱导的小鼠巨噬细胞 RAW 264.7 细胞中一氧化氮和 TNF-α 产生的能力。在所测试的化合物中，密花豆素 C（1）具有最强的抗炎作用，其降低 NO 产生的效果类似于地塞米松，降低 TNF-α 分泌的效果优于地塞米松。还分析了它们的构效关系。
Zotero 插件