Department of Pharmaceutics & Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.
Nat Prod Res. 2020 Apr;34(7):981-987. doi: 10.1080/14786419.2018.1547294. Epub 2019 Jan 12.
A new isoflavone, milletenol A (), along with four known flavonoids (-) were isolated from the seeds of . The structure of was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound and showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO-stimulated inflammation was effectively alleviated by compound in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.
从小米种子中分离得到一种新的异黄酮米利通醇 A（）以及四种已知的类黄酮（-）。通过广泛的光谱方法确定了的结构，而已知化合物则通过与文献数据进行比较来鉴定。化合物和对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮的产生具有显著的抗炎活性。化合物在斑马鱼中有效缓解了硫酸铜刺激引起的炎症状态。然而，在所分离的所有化合物中，对人乳腺癌细胞均无明显的细胞毒性。
