Gong Ting, Zhang Ting, Wang Dong-xiao, Chen Ruo-yun, Liu Ping, Yu De-quan
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China.
J Asian Nat Prod Res. 2014;16(2):181-6. doi: 10.1080/10286020.2013.860967. Epub 2013 Dec 11.
Two new isoflavone glycosides, millesianins F (1) and G (2), along with 11 known ones (3-13) have been isolated from the n-butanol extract of the vine stems of Millettia dielsiana Harms. The structures of 1 and 2 were established as cladrastin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (1) and fujikinetin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (2) by means of spectroscopic analysis and chemical methods. Some isolates (compounds 1, 3, 4, 5, 6, and 11) were tested for their effects on the proliferation of hematopoietic progenitor cell, and the preliminary results showed that all of investigated compounds had moderate activities but not in dose-dependent manners.
从香花崖豆藤（Millettia dielsiana Harms）藤茎的正丁醇提取物中分离得到了两种新的异黄酮苷，即密花豆素F（1）和G（2），以及11种已知化合物（3 - 13）。通过光谱分析和化学方法确定化合物1和2的结构分别为克拉司汀7 - O - β - d - 芹菜呋喃糖基 -（1→6）- β - d - 吡喃葡萄糖苷（1）和藤槐黄素7 - O - β - d - 芹菜呋喃糖基 -（1→6）- β - d - 吡喃葡萄糖苷（2）。对部分分离物（化合物1、3、4、5、6和11）进行了对造血祖细胞增殖影响的测试，初步结果表明，所有研究化合物均具有中等活性，但不呈剂量依赖性。
