HIV-1的长期储存库。
Long-lived reservoirs of HIV-1.
作者信息
Zaikos Thomas D, Collins Kathleen L
机构信息
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
出版信息
Trends Microbiol. 2014 Apr;22(4):173-5. doi: 10.1016/j.tim.2014.02.015. Epub 2014 Mar 15.
Abstract
HIV-1 persistence in long-lived cellular reservoirs remains a major barrier to a cure. In a recent Nature Medicine paper, Buzon et al. identify memory T cells with stem cell-like properties (TSCM) that harbor infectious provirus and that likely contribute to HIV-1 persistence.
摘要
HIV-1在长寿细胞储存库中的持续存在仍然是治愈的主要障碍。在最近发表于《自然·医学》的一篇论文中，布宗等人鉴定出了具有干细胞样特性的记忆T细胞（TSCM），这些细胞携带有传染性的前病毒，并且可能促成了HIV-1的持续存在。
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