60赫兹电场改变胰腺β细胞爆发期的膜电位：计算机模拟分析

60 Hz electric field changes the membrane potential during burst phase in pancreatic β-cells: in silico analysis.

作者信息

Neves Gesilda F, Silva José R F, Moraes Renato B, Fernandes Thiago S, Tenorio Bruno M, Nogueira Romildo A

机构信息

Laboratory of Theoretical, Computational and Experimental Biophysics, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.

出版信息

Acta Biotheor. 2014 Jun;62(2):133-43. doi: 10.1007/s10441-014-9214-z. Epub 2014 Mar 19.

DOI:10.1007/s10441-014-9214-z

PMID:24643285

Abstract

The production, distribution and use of electricity can generate low frequency electric and magnetic fields (50-60 Hz). Considering that some studies showed adverse effects on pancreatic β-cells exposed to these fields; the present study aimed to analyze the effects of 60 Hz electric fields on membrane potential during the silent and burst phases in pancreatic β-cells using a mathematical model. Sinusoidal 60 Hz electric fields with amplitude ranging from 0.5 to 4 mV were applied on pancreatic β-cells model. The sinusoidal electric field changed burst duration, inter-burst intervals (silent phase) and spike sizes. The parameters above presented dose-dependent response with the voltage amplitude applied. In conclusion, theoretical analyses showed that a 60 Hz electric field with low amplitudes changes the membrane potential in pancreatic β-cells.

摘要

电力的生产、分配和使用会产生低频电场和磁场（50 - 60赫兹）。鉴于一些研究表明暴露于这些场中的胰腺β细胞会受到不利影响；本研究旨在使用数学模型分析60赫兹电场对胰腺β细胞静息期和爆发期膜电位的影响。将幅度范围为0.5至4毫伏的正弦60赫兹电场施加于胰腺β细胞模型。正弦电场改变了爆发持续时间、爆发间期（静息期）和尖峰大小。上述参数呈现出与所施加电压幅度的剂量依赖性反应。总之，理论分析表明低幅度的60赫兹电场会改变胰腺β细胞的膜电位。