Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA (UK).
Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4181-5. doi: 10.1002/anie.201310056. Epub 2014 Mar 18.
This paper describes the hydrofluorination of alkenes through sequential H(-) and F(+) addition under palladium catalysis. The reaction is cis specific, thus providing access to benzylic fluorides. The mechanism of this reaction involves an ionic pathway and is distinct from known hydrofluorinations involving radical intermediates. The first catalytic enantioselective hydrofluorination is also disclosed.
本文描述了在钯催化下通过顺序的 H(-)和 F(+)加成实现的烯烃的氢氟化反应。该反应具有顺式特异性，因此可用于制备苄基氟化物。该反应的机理涉及离子途径，与涉及自由基中间体的已知氢氟化反应不同。本文还首次披露了首例催化对映选择性氢氟化反应。
