钴催化的非活化烯烃的氢氟化反应：氟转移的自由基途径。
Cobalt-catalyzed hydrofluorination of unactivated olefins: a radical approach of fluorine transfer.
机构信息
Faculty of Pharmacy, Musashino University , 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan.
出版信息
Org Lett. 2013 Oct 18;15(20):5158-61. doi: 10.1021/ol402696h. Epub 2013 Sep 30.
PMID:24079447
Abstract
Catalytic hydrofluorination of olefins using a cobalt catalyst was developed. The exclusive Markovnikov selectivity, functional group tolerance, and scalability of this reaction make it an attractive protocol for the hydrofluorination of olefins. A preliminary mechanistic experiment showed the involvement of a radical intermediate.
摘要
开发了一种使用钴催化剂的烯烃催化氢氟化反应。该反应具有独特的 Markovnikov 选择性、官能团耐受性和可扩展性，使其成为烯烃氢氟化的一种有吸引力的方法。初步的机理实验表明涉及自由基中间体。
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