Ayati Mohsen, Nowroozi Mohammad Reza, Jamshidian Hassan, Ayati Elnaz, Zarghan Farhad
Uro-Oncology Research Center (UoRC), Tehran University of Medical Sciences, Tehran, Iran.
Iran J Med Sci. 2014 Mar;39(2):140-3.
Lymph node (LN) metastasis is considered an important prognostic factor in patients with prostate cancer. The aim of this study was to determine the rate of LN metastasis among an Iranian population who underwent radical prostatectomy (RP) with pelvic LN dissection (PLND). In a retrospective review of medical records, 450 RP cases were included and the data on LN metastasis were extracted from surgical pathology reports. Overall, 4.7% of the patients had LN metastasis. The rate of surgical stage T3 (50% vs. 13.5%; P=0.021) and pathological Gleason score ³7 (82.4% vs. 48.8%; P=0.002) was significantly higher among LN-positive patients. All patients with LN metastasis had a serum prostate specific antigen level >4 ng/ml. The diagnosis of prostate cancer is in an acceptable, but not ideal, stage of the disease; this may be due to screening examinations and tests.
淋巴结（LN）转移被认为是前列腺癌患者的一个重要预后因素。本研究的目的是确定在接受根治性前列腺切除术（RP）并进行盆腔淋巴结清扫术（PLND）的伊朗人群中淋巴结转移率。在对病历的回顾性研究中，纳入了450例RP病例，并从手术病理报告中提取了有关淋巴结转移的数据。总体而言，4.7%的患者发生了淋巴结转移。淋巴结阳性患者的手术分期T3率（50%对13.5%；P=0.021）和病理Gleason评分≥7的比例（82.4%对48.8%；P=0.002）显著更高。所有发生淋巴结转移的患者血清前列腺特异性抗原水平均>4 ng/ml。前列腺癌的诊断处于疾病的一个可接受但不理想的阶段；这可能归因于筛查检查和检测。
