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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Balaton Limnological Research Institute, Hungarian Academy of Sciences, Tihany.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;91(2):337-41. doi: 10.1016/0742-8413(88)90039-4.

The effect of a pyrethroid insecticide deltamethrin was investigated on transient outward potassium currents of identified snail (Helix pomatia) neurones LPa1 and RPa3. 2. In 5 x 10(-5)M concentration the deltamethrin decreased the IA amplitude and the slope of I-V curve. The activation variable was shifted left along the voltage axis by 10-20 mV, while the inactivation variable remained unchanged. 3. Time constant of inactivation decreased, and the relaxation of IA described by one exponential. "Modified" ionic channel fraction was not observed. 4. It is suggested that deltamethrin acts on IA channels through a different molecular mechanism to INa channels, since not only the gating machinery but the permeability of the channels were influenced.

研究了拟除虫菊酯类杀虫剂溴氰菊酯对已鉴定的蜗牛（玛瑙螺）神经元LPa1和RPa3的瞬时外向钾电流的影响。2. 在5×10⁻⁵M浓度下，溴氰菊酯降低了IA幅度和I-V曲线的斜率。激活变量沿电压轴向左移动了10 - 20 mV，而失活变量保持不变。3. 失活的时间常数减小，IA的松弛由一个指数描述。未观察到“修饰”的离子通道部分。4. 表明溴氰菊酯通过与INa通道不同的分子机制作用于IA通道，因为不仅门控机制而且通道的通透性都受到了影响。

Balaton Limnological Research Institute, Hungarian Academy of Sciences, Tihany.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;91(2):337-41. doi: 10.1016/0742-8413(88)90039-4.

The effect of a pyrethroid insecticide deltamethrin was investigated on transient outward potassium currents of identified snail (Helix pomatia) neurones LPa1 and RPa3. 2. In 5 x 10(-5)M concentration the deltamethrin decreased the IA amplitude and the slope of I-V curve. The activation variable was shifted left along the voltage axis by 10-20 mV, while the inactivation variable remained unchanged. 3. Time constant of inactivation decreased, and the relaxation of IA described by one exponential. "Modified" ionic channel fraction was not observed. 4. It is suggested that deltamethrin acts on IA channels through a different molecular mechanism to INa channels, since not only the gating machinery but the permeability of the channels were influenced.

研究了拟除虫菊酯类杀虫剂溴氰菊酯对已鉴定的蜗牛（玛瑙螺）神经元LPa1和RPa3的瞬时外向钾电流的影响。2. 在5×10⁻⁵M浓度下，溴氰菊酯降低了IA幅度和I-V曲线的斜率。激活变量沿电压轴向左移动了10 - 20 mV，而失活变量保持不变。3. 失活的时间常数减小，IA的松弛由一个指数描述。未观察到“修饰”的离子通道部分。4. 表明溴氰菊酯通过与INa通道不同的分子机制作用于IA通道，因为不仅门控机制而且通道的通透性都受到了影响。