Gotman J, Koffler D J
Montreal Neurological Institute, McGill University, Montreal, Que., Canada.
Electroencephalogr Clin Neurophysiol. 1989 Jan;72(1):7-15. doi: 10.1016/0013-4694(89)90026-6.
In patients with focal epilepsy, EEG spike rate fluctuates considerably over time. We had previously shown that seizure occurrence played an important role in these fluctuations. We undertook this study to confirm this finding with better control of critical variables such as state of alertness and spike quantification, and to assess the spatial extent of the changes. Background activity changes and antiepileptic drug levels were also examined in relation to spiking. Spike discharge rate increased in the hours and days following seizures in widespread brain regions including, but not restricted to, the seizure focus. Spike rate did not change systematically before seizures. Postictal changes in background activity did not parallel spike fluctuations. Decreased antiepileptic drug levels did not cause increased spike rate. These results indicate that, following seizures, there is activation of interictal spiking which is not paralleled by changes in background activity. It is most often widespread and not necessarily most prominent at the site of seizure onset.
在局灶性癫痫患者中，脑电图棘波率随时间波动很大。我们之前已经表明，癫痫发作在这些波动中起重要作用。我们进行这项研究以更好地控制诸如警觉状态和棘波量化等关键变量来证实这一发现，并评估变化的空间范围。还检查了背景活动变化和抗癫痫药物水平与棘波发放的关系。在包括但不限于癫痫发作灶的广泛脑区，癫痫发作后的数小时和数天内棘波放电率增加。癫痫发作前棘波率没有系统性变化。发作后背景活动的变化与棘波波动不平行。抗癫痫药物水平降低并未导致棘波率增加。这些结果表明，癫痫发作后，发作间期棘波发放被激活，而背景活动没有相应变化。这种激活通常广泛存在，不一定在癫痫发作起始部位最为突出。
